Versatility of RNA-Binding Proteins in Living Cells
Versatility of RNA-Binding Proteins in Living Cells
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活细胞中 RNA 结合蛋白的多功能性
DOI：
10.11648/j.bs.20190501.12
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
R. Kurokawa et al.
中科院分区：
文献类型：
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作者：
Hamad Nesreen;Mashima Tsukasa;Yamaoki Yudai;Kondo Keiko;Yoneda Ryoma;Oyoshi Takanori;Kurokawa Riki;Nagata Takashi;Katahira Masato;R. Kurokawa et al.
本论文旨在证明RNA结合蛋白（RBP）及其相关RNA的复杂性或多样性。手稿中的数据基于2019年5月23日在京都大学东京办事处举行的RNA研究小组第三届年会。会议的目的是介绍研究小组的最新进展，并讨论RNA及其相关分子，特别是今年的RBP。我们进行了14次会议，并将其中10次记录在手稿中。有令人兴奋和富有成果的辩论。实际演示如下所示。特异性RBP Sfpq和Qk参与小鼠系统神经元发育。同样在小鼠中，液体和固体样RNA颗粒的形成在神经元功能中起着关键作用。生物化学实验表明，亲和谱将RNA结合蛋白分为不同的组。这为限制性商业惯例的生物差异提供了依据。在病理学的背景下，针对朊病毒和阿尔茨海默病的RNA适体可以呈现治疗结果。计算分析是解决RBP之谜的另一个工具。X染色体失活的研究是长链非编码RNA研究的前沿领域。lncRNA和LINE-1之间的冗余三链相互作用被认为是X染色体失活的关键。肌生成相关lncRNA，Myoparr通过调节
This conference paper aims at demonstration of complexity or multiplicity of RNA-binding protein (RBP) and its related RNA. The data in the manuscript are based upon the third Annual Meeting of the RNA study group, held at the Tokyo office of the Kyoto University on May 23 in 2019. The purpose of the meeting is to present recent progress of the study group and have discussion regarding RNA and related molecules, especially focusing on RBP in this year. We had fourteen sessions and documented ten of them in the manuscript. There were exciting and fruitful debates. Actual presentations are shown as follows. Specific RBP Sfpq and Qk are involved in neuronal development in mouse system. Also in mouse, liquid-and solid-like RNA granule formation plays pivotal roles in neuronal functions. Biochemical experiments demonstrate that affinity profiles categorize RNA-Binding proteins into distinctive groups. This presents basis for biological divergence of RBPs. In the context of pathology, RNA aptamers against prion and Alzheimer’s diseases may present therapeutic outcome. Computational analysis is another utility for approaching riddle of RBPs. The study of X-chromosome inactivation is pioneering field of long noncoding RNAs. Redundant triplex interactions between lncRNA and LINE-1s are supposed to be crucial in X-chromosome inactivation. Myogenesis-related lncRNA, Myoparr promotes skeletal muscle atrophy caused by denervation through the regulation of