Near-infrared Light Triggered-release in Deep Brain Regions Using Ultra-photosensitive Nanovesicles.
Near-infrared Light Triggered-release in Deep Brain Regions Using Ultra-photosensitive Nanovesicles.
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DOI：
10.1002/anie.201915296
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发表时间：
2020-03
影响因子：
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通讯作者：
H. Xiong;Xiuying Li;P. Kang;John M Perish;Frederik Neuhaus;J. Ploski;S. Kroener;Maria O. Ogunyankin;Jeong Eun Shin;J. Zasadzinski;Hui Wang;P. Slesinger;A. Zumbuehl;Zhenpeng Qin
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文献类型：
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作者：
H. Xiong;Xiuying Li;P. Kang;John M Perish;Frederik Neuhaus;J. Ploski;S. Kroener;Maria O. Ogunyankin;Jeong Eun Shin;J. Zasadzinski;Hui Wang;P. Slesinger;A. Zumbuehl;Zhenpeng Qin
Remote and minimally-invasive modulation of biological systems with light has transformed modern biology and neuroscience. However, light absorption and scattering significantly prevents penetration to deep brain regions. Here we describe the use of gold-coated mechanoresponsive nanovesicles, which consist of liposomes made from the artificial phospholipid Rad-PC-Rad as a tool for the delivery of bioactive molecules into brain tissue. Near-infrared picosecond laser pulses activated the gold-coating on the surface of nanovesicles, creating nanomechanical stress and leading to near-complete vesicle cargo release in sub-seconds. Compared to natural phospholipid liposomes, the photo-release was possible at 40 times lower laser energy. This high photosensitivity enables photorelease of molecules down to a depth of 4 mm in mouse brain. This promising tool provides a versatile platform to optically release functional molecules to modulate brain circuits.
