Local signaling within stem cell niches: insights from Drosophila.
Local signaling within stem cell niches: insights from Drosophila.
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DOI：
10.1016/j.ceb.2012.01.004
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发表时间：
2012-04
影响因子：
7.5
通讯作者：
Jones DL
中科院分区：
文献类型：
--
作者：
Resende LP;Jones DL
组织干细胞存在于特殊的微环境（生态位）中，在那里它们暴露于多种系统和局部信号，这些信号与细胞内在因子整合以调节干细胞行为。一般来说，系统信号用于协调组织对影响整个生物体的急性或长期变化的反应，例如营养可用性或衰老的变化。相反，局部信号传导通过平衡干细胞的自我更新与稳态条件下的分化以及响应局部损伤来调节组织维护。在这篇综述中，我们重点介绍了 JAK-STAT 通路在两个果蝇干细胞系统（睾丸和肠道）中的作用，并比较和对比了该通路的激活如何在稳态条件下以及响应应激或损伤时导致组织维持。
Tissue stem cells are found in specialized microenvironments (niches) where they are exposed to diverse systemic and local signals that are integrated with cell intrinsic factors to regulate stem cell behavior. In general, systemic signals are utilized to coordinate the response of tissues to acute or long-term changes that affect the whole organism, such as variations in nutrient availability or aging. In contrast, local signaling regulates tissue maintenance by balancing stem cell self-renewal with differentiation under homeostatic conditions and in response to local damage. In this review, we highlight the role of the JAK–STAT pathway in two Drosophila stem cell systems, the testis and intestine, and compare and contrast how activation of this pathway leads to tissue maintenance under both homeostatic conditions and in response to stress or injury.