Detection of enteric- and non-enteric adenoviruses in gastroenteritis patients, Bangladesh, 2012-2015
Detection of enteric- and non-enteric adenoviruses in gastroenteritis patients, Bangladesh, 2012-2015
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DOI：
10.1002/jmv.25008
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发表时间：
2018-04-01
影响因子：
12.7
通讯作者：
Rahman, Mustafizur
中科院分区：
文献类型：
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作者：
Afrad, Mokibul Hassan;Avzun, Tasnuva;Rahman, Mustafizur
人类腺病毒（HAdV）是世界范围内非细菌性急性胃肠炎的常见病因。关于孟加拉国急性胃肠炎相关HAdV分子流行病学的数据有限。我们描述了住院腹泻患者中HAdV的遗传多样性和流行病学，包括HAdV基因型、临床症状和合并感染的肠道病原体。从2012-2015年期间正在进行的腹泻监测中收集粪便样本。HAdV检测采用PCR和基因分型测序和系统发育分析。记录每例患者的详细社会人口统计学和临床信息，如腹泻持续时间、脱水状态、呕吐、腹痛、发热和严重程度。在871份粪便标本中，HAdV DNA检出93份（10.7%）。其中56%合并其他肠道病毒和细菌感染，31.6%合并严重胃肠炎。大多数（55%）HAdV阳性是儿童
Human adenoviruses (HAdVs) are common cause of nonbacterial acute gastroenteritis worldwide. Limited data exist on HAdVs molecular epidemiology associated with acute gastroenteritis in Bangladesh. We describe the genetic diversity and epidemiology of HAdVs among hospitalized diarrhea patients, including HAdV genotypes, clinical symptoms, and co-infecting enteric pathogens. Stool samples were collected from ongoing diarrhea surveillance during 2012-2015. HAdV was detected using PCR and genotyped by sequencing and phylogenetic analysis. Detailed socio-demographic and clinical information regarding each individual was recorded such as duration of diarrhea, dehydration status, vomiting, abdominal pain, fever, and severity. Of 871 fecal specimens, HAdV DNA was detected in 93 (10.7%). Among them 56% were co-infected with other known enteric viral and bacterial pathogens and 31.6% had severe gastroenteritis. The majority (55%) of HAdV positives were children