Chiari type I malformations in adults: a morphometric analysis of the posterior cranial fossa
Chiari type I malformations in adults: a morphometric analysis of the posterior cranial fossa
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DOI：
10.1016/j.surneu.2005.02.021
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发表时间：
2005-09-01
影响因子：
--
通讯作者：
Kaynar, MY
中科院分区：
文献类型：
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作者：
Aydin, S;Hanimoglu, H;Kaynar, MY
目的：基亚里I型畸形是一种先天性疾病，其特征是小脑扁桃体通过枕骨大孔向尾侧移位进入椎管。最近的研究表明，过度拥挤的后颅窝（PCF），因为不发达的骨骼结构在子宫内的生活是主要原因，这种畸形。出于这个原因，作者希望有助于目前的文献，重点是骨异常的PCF患者CMIS.Methods：我们研究了一个回顾性队列的60名成年患者与CMI，和多个测量磁共振成像。将结果与30名健康成年对照受试者进行比较。Mann-Whitney U检验作为统计学方法。结果：除枕骨大孔前后径外，所有测量值均较对照组减少。患者枕骨大孔前后正中矢状距离的增加与对照组相比达到统计学显著性差异。所有患者均在枕骨大孔平面下方至少5 mm处出现扁桃体疝。在这项研究中，基亚里I型畸形与46 patients.Conclusion：本研究与有限数量的患者表明，PCF的骨性成分没有充分发展，支持目前的概念，CMI是一种疾病的旁轴中胚层。(c)2005年爱思唯尔公司All rights reserved.
Objective: Chiari type I malformation (CMI) is a congenital disorder characterized by caudal displacement of the cerebellar tonsils through the foramen magnum into the spinal canal. Recent studies suggest that overcrowding in the posterior cranial fossa (PCF) because of underdeveloped bony structures in the intrauterine life is the main cause of this malformation. For this reason, the authors want to contribute to the current literature, which focuses on bone abnormalities in the PCF in patients with CMIs.Methods: We examined a retrospective cohort of 60 adult patients with CMIs, and multiple measurements were made on magnetic resonance imaging. The results were compared to 30 healthy adult control subjects. Mann-Whitney U test was used as a statistical method.Results: All measurements except mean anteroposterior diameter of the foramen magnum were reduced in patients compared to control. An increase in the anteroposterior mid-sagittal distance of the foramen magnum in patients reached statistically significant difference compared to control. All patients had tonsillar herniation at least 5 mm below the plane of the foramen magnum. Chiari type I malformation in this study was associated with syringomyelia in 46 patients.Conclusion: This study with a limited number of patients suggests that the bony components of the PCF are not developed fully, supporting the current concept that CMI is a disorder of the para-axial mesoderm. (c) 2005 Elsevier Inc. All rights reserved.