Autism and autism risk in siblings of children with specific language impairment.
Autism and autism risk in siblings of children with specific language impairment.
复制标题
有特定语言障碍的儿童的兄弟姐妹患有自闭症和自闭症风险。
DOI：
10.1080/1368282031000086363
复制
发表时间：
2003
影响因子：
2.4
通讯作者：
O'Brien,Marlea
中科院分区：
文献类型：
--
作者：
Tomblin,JBruce;Hafeman,LauraL;O'Brien,Marlea
背景：几项研究表明，自闭症儿童的家庭成员有较高的口头和书面言语和语言问题。目的：本研究询问，在有特殊语言障碍的先证者中，是否有更高比例的兄弟姐妹患有自闭症。方法与步骤：本研究先证者为158例特殊语言障碍儿童和132例语言正常儿童。这些先证者有522个兄弟姐妹，他们用自闭症行为检查表检查了患自闭症的风险。然后使用自闭症诊断访谈-修订版和自闭症诊断观察表- G对发现有风险的兄弟姐妹进行检查。结果与结果：发现有自闭症风险的兄弟姐妹集中与口语能力差的先证者有关。522名儿童中有4名（0.8%）符合自闭症诊断标准。这些兄弟姐妹的先证者口语得分均低于- 1 SD，其中3人被诊断为口语障碍。结论：这些数据为自闭症和口语障碍之间的家族关联提供了额外的支持。
Background: Several studies have shown that family members of children with autism have elevated rates of spoken and written speech and language problems. Aims: This study asked whether there was also a greater rate of siblings with autism among probands with specific language impairment.Methods & Procedures: The probands in this study were 158 children with specific language impairment and 132 children with normal language status. These probands had 522 siblings who were examined for risk of autism using the Autism Behavior Checklist. Siblings found to be at risk were then examined using the Autism Diagnostic Interview—Revised and the Autism Diagnostic Observation Schedule‐G.Outcomes & Results: A concentration of siblings with risk for a diagnosis of autism was found in association with probands who had poor spoken language skills. Four siblings of the 522 (0.8%) met the diagnostic standards for autism. All the probands of these siblings had spoken language scores below − 1 SD and three had diagnoses of spoken language impairment.Conclusions: These data provide additional support for a familial association between autism and spoken language impairment.