Metastatic diversity in human prostatic carcinoma: implications of growth factors and growth factor receptors for the metastatic phenotype.

Metastatic diversity in human prostatic carcinoma: implications of growth factors and growth factor receptors for the metastatic phenotype.
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人类前列腺癌的转移多样性:生长因子和生长因子受体对转移表型的影响。

DOI:
10.1159/000157154
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发表时间:
1989
期刊:
Pathology and immunopathology research
影响因子:
--
通讯作者:
Maygarden,SJ
Maygarden,SJ
中科院分区:
--
文献类型:
--
作者:
Ware,JL;Maygarden,SJ

文献摘要

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人类前列腺癌进展的细胞和分子基础仍然知之甚少。前列腺癌是美国男性中最常见的癌症[1],其临床过程可能相对缓慢[2]或迅速进展为播散性转移[3]。由于很少有可靠的预后指标预测前列腺肿瘤的病理生物学行为,这种疾病的治疗总是伴随着不确定性[4-6],
The cellular and molecular basis for the progression of human prostatic cancer reн mains poorly understood. The clinical course of prostatic carcinoma, the most comн mon cancer occurring among American men [1], may be relatively indolent [2] or advance rapidly to disseminated metastases [3]. Beн cause there are few prognostic indicators which reliably predict the pathobiological behavior of prostatic tumors, treatment of this disease is invariably accompanied by uncertainty [4-6],