Hypertrophy of colonic smooth muscle: structural remodeling, chemical composition, and force output.
Hypertrophy of colonic smooth muscle: structural remodeling, chemical composition, and force output.
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结肠平滑肌肥大：结构重塑、化学成分和力量输出。
DOI：
10.1152/ajpgi.1997.272.6.g1560
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Starcher,BC
中科院分区：
文献类型：
--
作者：
Siegman,MJ;Butler,TM;Mooers,SU;Trinkle-Mulcahy,L;Narayan,S;Stirewalt,WS;Starcher,BC
The cellular basis of adaptations occurring during the development of megacolon was studied with the lethal spotted mouse model. Age-dependent changes in the length-force characteristics of the colon reach a steady state by 3-4 mo and include an increased relative force development at very short muscle lengths. In megacolon the following occur: 1) structural remodeling expressed as a greater increase in the fraction of maximum force production at short lengths, a shift of optimum length (Lo) to longer lengths, and no change in force per square centimeter; 2) hypertrophy and hyperplasia of both circular and longitudinal muscle; 3) high resting compliance consistent with no disproportionate change in collagen or elastin composition; 4) marked distension so that in situ circumference approximately 1.8 Lo, where active force production is low, and 5) slack length approximately 0.65 Lo, as in normal colon. Biochemical remodeling in megacolon includes disproportionate increases in ATP and phosphocreatine concentration, with 3.5-fold more preformed phosphagen than in normal colon. The myosin concentration is the same in both muscles, but the actin concentration is 1.5-fold greater in megacolon. Most of the cellular changes in megacolon would facilitate high active force output from the muscle at much larger intestinal diameters.
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结肠平滑肌肥大：收缩蛋白、缩短速度和调节。
DOI：
10.1152/ajpgi.1997.272.6.g1571
发表时间：
1997
期刊：
The American journal of physiology.
影响因子：
--
作者：
Siegman,MJ;Butler,TM;Mooers,SU;Trinkle-Mulcahy,L;Narayan,S;Adam,L;Chacko,S;Haase,H;Morano,I
通讯作者：
Morano,I
DOI：
10.1083/jcb.52.1.105
发表时间：
1972-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cooke PH;Fay FS
通讯作者：
Fay FS
兔和人子宫肌层的长度-张力关系
DOI：
10.1113/jphysiol.1964.sp007507
发表时间：
1964
期刊：
The Journal of Physiology
影响因子：
--
作者：
B. Schofield;C. Wood
通讯作者：
C. Wood
影响因子：
6
作者：
B. Meyrick;L. Reid
通讯作者：
L. Reid
妊娠子宫肌层的伸展性增强
DOI：
10.1113/jphysiol.1966.sp007845
发表时间：
1966
期刊：
The Journal of Physiology
影响因子：
--
作者：
B. Schofield
通讯作者：
B. Schofield