Brief report: parental age and the sex ratio in autism.
Brief report: parental age and the sex ratio in autism.
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DOI：
10.1007/s10803-009-0755-y
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发表时间：
2009-10
影响因子：
3.9
通讯作者：
Silverman, Jeremy M.
中科院分区：
文献类型：
--
作者：
Anello, Alene;Reichenberg, Abraham;Luo, Xiaodong;Schmeidler, James;Hollander, Eric;Smith, Christopher J.;Puleo, Connor M.;Kryzak, Lauren A.;Silverman, Jeremy M.
自闭症谱系障碍（ASD）的男女比例（M：F）通常约为4：1，似乎随着父亲年龄的增加而下降，但这种关系尚未得到系统的测试。我们将来自两个或两个以上ASD病例家庭的393例ASD病例分为五个年龄组（<30岁，30-34岁，35-39岁，40-44岁，45岁以上），发现M：F比值随着父亲年龄组的增加而显著降低，并在调整母亲年龄后保持不变。未观察到母亲年龄组与M：F比值之间的显著关系。这项研究表明，随着父亲年龄的增加，M：F比率降低，这与新生遗传或基因组异常随着男性年龄的增长而更频繁地出现，然后怀孕。
The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30–34, 35–39, 40–44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children.
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影响因子：
158.5
作者：
Weiss, Lauren A.;Shen, Yiping;Daly, Mark J.
通讯作者：
Daly, Mark J.
影响因子：
3.9
作者：
Lord, C;Risi, S;Rutter, M
通讯作者：
Rutter, M
DOI：
10.1073/pnas.0705803104
发表时间：
2007-07-31
影响因子：
11.1
作者：
Zhao, Xiaoyue;Leotta, Anthony;Wigler, Michael
通讯作者：
Wigler, Michael
影响因子：
11
作者：
Ma, D. Q.;Cuccaro, M. L.;Pericak-Vance, M. A.
通讯作者：
Pericak-Vance, M. A.
影响因子：
56.9
作者：
Sebat, Jonathan;Lakshmi, B.;Wigler, Michael
通讯作者：
Wigler, Michael