Frequent presence of a novel herpesvirus genome in lesions of human immunodeficiency virus-negative Kaposi's sarcoma
Frequent presence of a novel herpesvirus genome in lesions of human immunodeficiency virus-negative Kaposi's sarcoma
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DOI：
10.1093/infdis/173.1.248
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发表时间：
1996-01-01
影响因子：
6.4
通讯作者：
Ganem, D
中科院分区：
文献类型：
--
作者：
Chuck, S;Grant, RM;Ganem, D
虽然卡波西氏肉瘤(KS)在感染人类免疫缺陷病毒(HIV)的同性恋者中非常常见，但它也在几个没有感染HIV的临床环境中发现。最近，疱疹病毒家族中一个新成员的基因组序列在与艾滋病相关的KS活组织检查中被发现。在6例HIV阴性的KS中发现了这些序列，其中包括4例来自非洲的地方性KS，并在6例中的5例中发现了这些序列。这些发现加强了这种病毒感染与KS发展之间的联系，并反对这种联系只是严重免疫缺陷宿主机会性重叠感染的结果。
While Kaposi's sarcoma (KS) is extremely common in homosexual men infected with human immunodeficiency virus (HIV), it is also found in several clinical settings in which HIV infection is absent. Recently, sequences from the genome of a novel member of the herpesvirus family have been identified within KS biopsies in the AIDS-associated form of the disease. The presence of these sequences was sought in 6 cases of HIV-negative KS, including 4 cases of endemic KS from Africa, and was found in 5 of the 6. These findings strengthen the association between infection with this virus and the development of KS and argue against the notion that this association is simply the result of opportunistic superinfection of profoundly immunodeficient hosts.