PUBLIC DRINKING-WATER CONTAMINATION AND BIRTH OUTCOMES
PUBLIC DRINKING-WATER CONTAMINATION AND BIRTH OUTCOMES
复制标题
DOI：
10.1093/oxfordjournals.aje.a117521
复制
发表时间：
1995-05-01
影响因子：
5
通讯作者：
SAVRIN, JE
中科院分区：
文献类型：
--
作者：
BOVE, FJ;FULCOMER, MC;SAVRIN, JE
在新泽西州北部的一个地区评估了公共饮用水污染对出生结果的影响，在排除多胎出生和染色体缺陷后，对 1985 年至 1988 年期间发生的 80,938 例活产和 594 例胎儿死亡进行了研究。有关出生结果状态和孕产妇危险因素的信息来自重要记录和新泽西州出生缺陷登记处。使用自来水样本数据估算所有新生儿在怀孕期间的每月暴露量。以下情况的比值比大于或等于 1.50：总三卤甲烷小于胎龄、中枢神经系统缺陷、口腔裂缺陷和主要心脏缺陷；四氯化碳足月低出生体重、小于胎龄、极低出生体重、全面监测出生缺陷、中枢神经系统缺陷、神经管缺陷、口裂缺陷；三氯乙烯与中枢神经系统缺陷、神经管缺陷和口腔裂缺陷；四氯乙烯导致口腔裂隙缺陷；总二氯乙烯与中枢神经系统缺陷和口腔裂缺陷；苯导致神经管缺陷和严重心脏缺陷； 1,2-二氯乙烷具有严重的心脏缺陷。总三卤甲烷水平 >100 ppb 会使足月产的出生体重减少 70.4 克。就其本身而言，这项研究无法解决饮用水污染物是否导致不良出生结局的问题；因此，应利用现有的饮用水污染数据库对这些发现进行跟踪。
The effects of public drinking water contamination on birth outcomes were evaluated in an area of northern New Jersey, After excluding plural births and chromosomal defects, 80,938 live births and 594 fetal deaths that occurred during the period 1985-1988 were studied. Information on birth outcome status and maternal risk factors was obtained from vital records and the New Jersey Birth Defects Registry. Monthly exposures during pregnancy were estimated for all births using tap water sample data. Odds ratios of greater than or equal to 1.50 were found for the following: total trihalomethanes with small for gestational age, central nervous system defects, oral cleft defects, and major cardiac defects; carbon tetrachloride with term low birth weight, small for gestational age, very low birth weight, total surveillance birth defects, central nervous system defects, neural tube defects, and oral cleft defects; trichloroethylene with central nervous system defects, neural tube defects, and oral cleft defects; tetrachloroethylene with oral cleft defects; total dichloroethylenes with central nervous system defects and oral cleft defects; benzene with neural tube defects and major cardiac defects; and 1,2-dichloroethane with major cardiac defects. Total trihalomethane levels >100 ppb reduced birth weight among term births by 70.4 g. By itself, this study cannot resolve whether the drinking water contaminants caused the adverse birth outcomes; therefore, these findings should be followed up utilizing available drinking water contamination databases.