A CANINE MODEL OF ACUTE HINDBRAIN ISCHEMIA AND REPERFUSION
A CANINE MODEL OF ACUTE HINDBRAIN ISCHEMIA AND REPERFUSION
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DOI：
10.1227/00006123-199505000-00015
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发表时间：
1995-05-01
期刊：
影响因子：
4.8
通讯作者：
BATJER, HH
中科院分区：
文献类型：
--
作者：
GUO, J;LIAO, JJ;BATJER, HH
脑干缺血的动物模型需要用于病理生理学研究和治疗评估；目前很少有这样的模型可用。本文介绍了一种新的犬后脑缺血和再灌注模型。通过颈前入路，手术暴露 18 只狗的基底动脉。用氰基丙烯酸酯胶栓塞后交通动脉和小脑上动脉，以将后循环与前循环隔离。通过临时夹闭不同时期（10-30 分钟）的椎动脉和腹侧脊髓动脉，在 14 只狗中诱导可逆性后脑缺血，然后移除夹子并实现再灌注 5 小时。在所有 14 只狗中，基底动脉灌注压下降证实了后脑缺血（
ANIMAL MODELS OF brain stem ischemia are needed for pathophysiological study and evaluation of treatment; few such models are available currently. A new canine model of hindbrain ischemia and reperfusion is introduced in this article. Through an anterior cervical approach, the basilar artery was surgically exposed in 18 dogs. The posterior communicating and superior cerebellar arteries were embolized with cyanoacrylate glue to isolate the posterior circulation from the anterior circulation. Reversible hindbrain ischemia was induced in 14 dogs by the temporary clipping of the vertebral and ventral spinal arteries for various periods (10-30 min), then the clips were removed and reperfusion was achieved for 5 hours. In all 14 dogs, the hindbrain ischemia was confirmed by the decreased perfusion pressure in the basilar artery(