Mechanisms of Vascular Aging.
Mechanisms of Vascular Aging.
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DOI：
10.1161/circresaha.118.311378
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发表时间：
2018-09-14
影响因子：
20.1
通讯作者：
Csiszar A
中科院分区：
文献类型：
--
作者：
Ungvari Z;Tarantini S;Donato AJ;Galvan V;Csiszar A
脉管系统的老化在老年人的发病率和死亡率中起着核心作用。为了开发新的治疗方法来改善不成功的血管老化和预防与年龄相关的血管病变，有必要了解血管在衰老过程中发生的细胞和功能变化。在这篇综述中，衰老的基本细胞和分子机制的病理生理作用，包括氧化应激、线粒体功能障碍、对分子应激源的抵抗力受损、慢性低度炎症、基因组不稳定、细胞衰老、表观遗传改变、蛋白质稳态丧失、在与老年相关的微血管和大血管疾病的发病机制中，血管系统中的营养感知失调和干细胞功能障碍被认为是它们的贡献。讨论了促衰老和抗衰老循环因子在血管衰老表型发展中的重要性。最后，提出了未来的发展方向和机会，开发新的干预措施，以预防/延缓与年龄相关的血管病变，通过针对基本的细胞和分子老化过程。
Aging of the vasculature plays a central role in morbidity and mortality of older people. In order to develop novel treatments for amelioration of unsuccessful vascular aging and prevention of age-related vascular pathologies it is essential to understand the cellular and functional changes that occur in the vasculature during aging. In this review, the pathophysiological roles of fundamental cellular and molecular mechanisms of aging, including oxidative stress, mitochondrial dysfunction, impaired resistance to molecular stressors, chronic low-grade inflammation, genomic instability, cellular senescence, epigenetic alterations, loss of protein homeostasis, deregulated nutrient sensing and stem cell dysfunction in the vascular system are considered in terms of their contribution to the pathogenesis of both micro- and macrovascular diseases associated with old age. The importance of pro-geronic and anti-geronic circulating factors in relation to development of vascular aging phenotypes are discussed. Finally, future directions and opportunities to develop novel interventions to prevent/delay age-related vascular pathologies by targeting fundamental cellular and molecular aging processes are presented.