Conditioned social preference, but not place preference, produced by intranasal oxytocin in female mice.
Conditioned social preference, but not place preference, produced by intranasal oxytocin in female mice.
复制标题
雌性小鼠鼻内催产素产生条件性社会偏好，但不是地点偏好。
DOI：
10.1037/bne0000139
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发表时间：
2016
影响因子：
1.9
通讯作者：
S.
中科院分区：
文献类型：
--
作者：
Kosaki;Y.;Watanabe;S.
催产素（OT）与多种哺乳动物的生殖和社会行为有关，并且鼻内OT用于临床目的的使用正在增加。然而，OT的基本作用，包括药物的奖励或强化特性，目前还没有完全了解。在这项研究中，作者研究了鼻内给药OT是否对社会和非社会刺激具有不同的强化特性，以及这种效应在男性和女性受试者之间是否存在差异。本研究采用条件性社会偏好（CSP）和条件性位置偏好（CPP）范式考察了OT的社会和非社会强化特性。在CSP中，一种不熟悉的同性同种的存在与鼻内OT反复配对，而不同的同种与生理盐水相关。在无药物条件下，在后处理选择测试中评估OT的强化效果。在CPP中，2个同种被非社会性的黑色和白色隔间所取代。作者发现，雌性鼻内OT（12 μg）支持CSP（实验1）而不是CPP（实验3）的形成。雄性动物中既未形成CSP（实验2），也未形成CPP（实验4）。然而，高剂量OT（36 μg）的延长条件反射消除了雌性小鼠的初始CSP，并产生了对OT配对刺激小鼠的厌恶。实验5表明，是重复给药而不是更高的剂量导致了最初偏好的消除。总体而言，目前的结果首次证明了小鼠鼻内OT的性别和刺激依赖性增强特性。
Oxytocin (OT) has been implicated in a variety of mammalian reproductive and social behaviors, and the use of intranasal OT for clinical purposes is on the rise. However, basic actions of OT, including the rewarding or reinforcing properties of the drug, are currently not fully understood. In this study, the authors investigated whether intranasally administered OT has different reinforcing properties for social and nonsocial stimuli and whether such effects are variable between male and female subjects. Conditioned social preference (CSP) and conditioned place preference (CPP) paradigms were used to examine social and nonsocial reinforcing properties of OT. In CSP, the presence of a same-sex unfamiliar conspecific was repeatedly paired with intranasal OT, while a different conspecific was associated with saline. The reinforcing effect of OT was assessed in a postconditioning choice test under a drug-free condition. In CPP, the 2 conspecifics were replaced with nonsocial black and white compartments. The authors found that intranasal OT (12 μg) in females supported the formation of CSP (Experiment 1) but not CPP (Experiment 3). Neither CSP (Experiment 2) nor CPP (Experiment 4) was formed in males. Extended conditioning with higher dose OT (36 μg), however, abolished the initial CSP in females and produced an aversion to the OT-paired stimulus mouse. Experiment 5 indicated that it was the repeated administrations rather than the higher dose that produced the abolition of the original preference. Overall, the current results demonstrate for the first time a sex-and stimulus-dependent reinforcing property of intranasal OT in mice.