Tissue thioredoxin-interacting protein expression predicted recurrence in patients with meningiomas
Tissue thioredoxin-interacting protein expression predicted recurrence in patients with meningiomas
复制标题
组织硫氧还蛋白相互作用蛋白表达预测脑膜瘤患者的复发
DOI：
10.1007/s10147-017-1103-4
复制
发表时间：
2017-08-01
影响因子：
3.3
通讯作者：
Hu, Guohan
中科院分区：
文献类型：
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作者：
Cai, Zheng;Zhang, Chenran;Hu, Guohan
研究背景氧化还原调节蛋白硫氧还蛋白相互作用蛋白（thioredoxin-interacting protein，TXNIP）已被证实是人类多种肿瘤的重要抑癌基因。在以往的研究中，我们通过微阵列数据分析发现，肿瘤抑制基因RIZ 1在脑膜瘤中的过表达可以显著提高TXNIP的表达。因此，我们假设TXNIP与脑膜瘤的发生和发展有关。方法首先，我们采用免疫组化方法检测了65例脑膜瘤组织中TXNIP和Ki-67的表达。结果高级别脑膜瘤组织中TXNIP的表达明显低于良性脑膜瘤组织（29.31 ± 18.70 vs74.61 ± 7.51，P < 0.0001）; TXNIP与Ki 67呈负相关（P < 0.0001）。TXNIP在无复发的高级别脑膜瘤中的表达明显高于无复发的高级别脑膜瘤（P < 0.05）。Kaplan-Meier分析显示TXNIP和Ki-67的表达与无复发时间有关。多因素考克斯分析显示TXNIP表达水平是脑膜瘤预后的唯一独立预测因子。结论TXNIP高表达提示脑膜瘤病理分级低，无复发时间长。因此，TXNIP可作为预测脑膜瘤复发的潜在分子标志物。
Background The redox regulatory protein, thioredoxin-interacting protein (TXNIP), has been confirmed as an important tumor suppressor gene in various types of human cancers. In previous studies, we found that overexpression of tumor suppressor gene RIZ1 in meningiomas can significantly improve the expression of TXNIP by microarray data analysis. Therefore, we hypothesized that TXNIP was associated with the initiation and progression of meningiomas.Methods First, we evaluated the expression of TXNIP and Ki-67 in meningioma tissues from 65 patients using immunohistochemistry. We also analyzed the correlation between TXNIP immunoreactivity and clinicopathological features, as well as patient prognostic factors.Results According to immunohistochemistry results, high-grade meningioma tissues had significantly lower expression of TXNIP than benign meningioma tissues (29.31 +/- 18.70 vs 74.61 +/- 7.51, P < 0.0001). TXNIP and Ki67 were negatively correlated (P < 0.0001). Moreover, the expression of TXNIP was higher in nonrecurrent high-grade meningiomas (P < 0.05). In addition, Kaplan-Meier analysis indicated that expression of TXNIP and Ki-67 was related to recurrence-free time. Multivariate Cox analysis showed that TXNIP expression level was the only independent predictor for meningioma prognosis.Conclusion Our results demonstrated that high expression of TXNIP indicates a lower pathological grade of meningnioma, and is also associated with longer recurrence-free time. Therefore, TXNIP could be regarded as a potential molecular marker to predict recurrence in patients with meningiomas.