Neutron scattering in the biological sciences: progress and prospects
Neutron scattering in the biological sciences: progress and prospects
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DOI：
10.1107/s2059798318017503
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发表时间：
2018-12-01
影响因子：
2.2
通讯作者：
Smith, Jeremy C.
中科院分区：
文献类型：
--
作者：
Ashkar, Rana;Bilheux, Hassina Z.;Smith, Jeremy C.
中子的散射可以用来提供关于生物系统在多个长度和时间尺度上的结构和动力学的信息。根据2018年2月国家科学基金会资助的研讨会，本文回顾了该领域的最新发展，以及考虑到来源，仪器和计算能力和方法的最新进展，可以预期的未来前景。晶体学，溶液散射，动力学，膜，标记和成像进行检查。为了最大限度地提取信息，明智的具体氘标记，集成几种类型的实验，并使用高性能的计算机模拟模型的解释往往被发现是特别强大的。
The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.