Results after microfracture of full-thickness chondral defects in different compartments in the knee
Results after microfracture of full-thickness chondral defects in different compartments in the knee
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DOI：
10.1016/j.joca.2006.05.003
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发表时间：
2006-11-01
影响因子：
7
通讯作者：
Suedkamp, N.
中科院分区：
文献类型：
--
作者：
Kreuz, P. C.;Steinwachs, M. R.;Suedkamp, N.
目的：确定全厚性软骨损伤微裂缝后的临床结果是否在36个月的时间内恶化：在1999年至2002年之间，有85例患者（平均年龄39.5岁），具有全厚性软骨病变，并经过了术前进行了评估，并接受了术前的评估。手术后的6、18和36个月。排除标准是半月板病理，轴向不良置换和韧带不稳定性。将基线的临床评分与经过改装的辛辛那提膝盖的配对Wilcoxon检验和国际软骨修复学会（ICRS） - 分数进行了比较。使用Pearson相关性和独立样品测试评估病变定位和磁共振成像（MRI）参数的影响。分辨率：两个分数在微裂纹后18个月均显着改善（P <0.0001）。在手术后的第二个18个月内，ICRS得分有显着恶化（P <0.0001）。最好的结果可以在股骨con的软骨病变中观察到。膝盖其他区域的缺陷在微骨折后的18至36个月之间恶化。手术后36个月的MRI显示股con上的病变最佳缺陷填充，其他区域有显着差异（p <0.02）。缺陷填充和ICRS得分之间的皮尔逊相关系数为0.84，在0.01水平下显着。结论：微裂纹是一种最小的侵入性方法，在治疗小软骨缺陷方面具有良好的短期结果。结果的恶化开始于手术后18个月，在ICRS得分中最为明显。最好的预后因素使年轻的患者患有股con的缺陷。 （c）2006年由Elsevier Ltd代表国际骨关节炎研究协会出版。
Objective: To determine if the clinical results after microfracture of full-thickness cartilage lesions deteriorate over a period of 36 monthsMethods: Between 1999 and 2002 85 patients (mean age 39.5 years) with full-thickness cartilage lesions underwent the microfracture procedure and were evaluated preoperatively and 6, 18 and 36 months after surgery. Exclusion criteria were meniscal pathologies, axial mal-positioning and ligament instabilities. Baseline clinical scores were compared with follow-up data by paired Wilcoxon-tests for the modified Cincinnati knee and the International Cartilage Repair Society (ICRS)-score. The effects of the lesion localization and Magnetic resonance imaging (MRI) parameters were evaluated using the Pearson correlation and independent samples tests.Results: Both scores revealed significant improvement 18 months after microfracture (P < 0.0001). Within the second 18 months after surgery there was a significant deterioration in the ICRS-score (P < 0.0001). The best results could be observed in chondral lesions of the femoral condyles. Defects in other areas of the knee deteriorated between 18 and 36 months after microfracture. MRI 36 months after surgery revealed best defect filling in lesions on the femoral condyles with significant difference in the other areas (P < 0.02). The Pearson coefficient of correlation between defect filling and ICRS-score was 0.84 and significant at the 0.01 level.Conclusions: Microfracture is a minimal invasive method with good short-term results in the treatment of small cartilage defects. A deterioration of the results starts 18 months after surgery and is most evident in the ICRS-score. The best prognostic factors have young patients with defects on the femoral condyles. (C) 2006 Published by Elsevier Ltd on behalf of OsteoArthritis Research Society International.