The interactive online SKY/M-FISH & CGH database and the Entrez cancer chromosomes search database: Linkage of chromosomal aberrations with the genome sequence
The interactive online SKY/M-FISH & CGH database and the Entrez cancer chromosomes search database: Linkage of chromosomal aberrations with the genome sequence
复制标题
DOI：
10.1002/gcc.20224
复制
发表时间：
2005-09-01
影响因子：
3.7
通讯作者：
Ried, T
中科院分区：
文献类型：
--
作者：
Knutsen, T;Gobu, V;Ried, T
为了对来自新兴分子细胞遗传学技术的癌症染色体畸变数据进行编目，并将这些数据与基因组图谱整合，我们建立了两个资源，NCI和NCBI SKY/M-FISH & CGH数据库和癌症染色体数据库。前者的目标是允许研究者提交和分析临床和研究细胞遗传学数据。它包含一个核型分析器工具，可以自动将ISCN短型核型转换为以详细形式显示的内部表示，并显示为带重叠的彩色表意符号，还具有一个工具来比较多个病例的CGH图谱。癌症染色体数据库整合了SKY/M-FISH & CGH数据库、Mitelman癌症染色体畸变数据库和癌症复发性染色体畸变数据库。这三个数据集现在可以通过使用染色体畸变、临床数据和参考文献引用的Zeroz搜索和检索系统进行无缝搜索。共同的诊断，解剖部位，染色体断裂点，路口，数量和结构异常，并获得和丢失的带在选定的情况下，可以通过使用“相似性”的报告进行比较。因为用于CGH数据的模型是核型数据的子集，所以现在可以直接检查CGH结果和核型之间的相似性。所有染色体条带都直接链接到Tiberz Map Viewer数据库，提供细胞遗传学数据与序列组装的整合。这些资源是作为癌症染色体畸变项目（CCAP）倡议的一部分开发的，有助于寻找新的癌症相关基因，并促进对癌症遗传改变的原因和后果的深入了解。2005年出版Wiley-Liss，Inc.
To catalog data on chromosomal aberrations in cancer derived from emerging molecular cytogenetic techniques and to integrate these data with genome maps, we have established two resources, the NCI and NCBI SKY/M-FISH & CGH Database and the Cancer Chromosomes database. The goal of the former is to allow investigators to submit and analyze clinical and research cytogenetic data. It contains a karyotype parser tool, which automatically converts the ISCN short-form karyotype into an internal representation displayed in detailed form and as a colored ideogram with band overlay, and also has a tool to compare CGH profiles from multiple cases. The Cancer Chromosomes database integrates the SKY/M-FISH & CGH Database with the Mitelman Database of Chromosome Aberrations in Cancer and the Recurrent Chromosome Aberrations in Cancer database. These three datasets can now be searched seamlessly by use of the Entrez search and retrieval system for chromosome aberrations, clinical data, and reference citations. Common diagnoses, anatomic sites, chromosome breakpoints, junctions, numerical and structural abnormalities, and bands gained and lost among selected cases can be compared by use of the "similarity" report. Because the model used for CGH data is a subset of the karyotype data, it is now possible to examine the similarities between CGH results and karyotypes directly. All chromosomal bands are directly linked to the Entrez Map Viewer database, providing integration of cytogenetic data with the sequence assembly. These resources, developed as a part of the Cancer Chromosome Aberration Project (CCAP) initiative, aid the search for new cancer-associated genes and foster insights into the causes and consequences of genetic alterations in cancer. Published 2005 Wiley-Liss, Inc.