Late results of reconstruction of the right ventricular outflow tract with porcine xenografts in children.
Late results of reconstruction of the right ventricular outflow tract with porcine xenografts in children.
复制标题
儿童猪异种移植物重建右心室流出道的最新结果。
DOI：
10.1016/s0003-4975(10)60998-8
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Kaplan,S
中科院分区：
文献类型：
--
作者：
Bisset3rd,GS;Schwartz,DC;Benzing3rd,G;Helmsworth,J;Schreiber,JT;Kaplan,S
33名儿童，年龄2.5 - 17.5岁（平均8.3岁），右心室和肺动脉之间放置异种移植物外管道，术后随访1 - 6年（平均3.5年）。研究组中没有晚期死亡，也没有证明带瓣管道感染。这些儿童中有20人在随访期间接受了导管插入术。右心室至肺动脉的压差范围为8 ~ 90 mm Hg（平均31 mm Hg）。共有8例患者被归类为具有血流动力学记录的管道故障，另外2例患者在临床上预期具有管道故障。这表示在6年随访中异种移植物管道失效的总发生率为30%。虽然这种功能障碍的病因可能是多因素的，如瓣膜尺寸，管道成角，和免疫能力的因素承担特殊consideration.We的结论是，虽然带瓣外部管道继续发挥重要作用，在复杂的先天性心脏病的治疗，需要一个带瓣管道更长的寿命用于儿童。
Thirty-three children, aged 2.5 to 17.5 years (mean, 8.3 years), having xenograft external conduits placed between the right ventricle and pulmonary artery were followed for 1 to 6 years postoperatively (mean, 3.5 years). There were no late deaths in the study group, and no infection of a valved conduit has been demonstrated. Twenty of these children were catheterized during the follow-up period. The gradients from the right ventricle to pulmonary artery ranged from 8 to 90 mm Hg (average, 31 mm Hg). A total of 8 patients were classified as having hemodynamically documented conduit failure, and an additional 2 patients are clinically expected to have conduit failure. This represents a total incidence of 30% xenograft conduit failure in a 6-year follow-up. Although the etiology of this dysfunction is probably multifactorial, factors such as valve size, conduit angulation, and immunological competence bear special consideration.We conclude that although valved external conduits continue to play an important role in the treatment of complex congenital heart disease, a valved conduit with greater longevity is needed for use in children.