Metabolic regulation via enzyme filamentation.
Metabolic regulation via enzyme filamentation.
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DOI：
10.3109/10409238.2016.1172555
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发表时间：
2015-07
影响因子：
6.5
通讯作者：
Liu JL
中科院分区：
文献类型：
--
作者：
Aughey GN;Liu JL
确定酶调节的机制是细胞代谢研究的核心。通过聚合介导的策略调节酶活性已被证明是广泛的，并且在介导细胞内稳态中起着至关重要的作用。在这篇综述中，我们开始概述CTP合成酶的成丝作用，它形成称为细胞蛇的丝状结构。然后，我们强调这一现象的其他重要例子。此外，我们讨论了最近的数据有关的酶活性的调节划分成cytophidia。最后，我们假设酶丝形成在代谢，发育和疾病的调节中的潜在作用。
Determining the mechanisms of enzymatic regulation is central to the study of cellular metabolism. Regulation of enzyme activity via polymerization-mediated strategies has been shown to be widespread, and plays a vital role in mediating cellular homeostasis. In this review, we begin with an overview of the filamentation of CTP synthase, which forms filamentous structures termed cytoophidia. We then highlight other important examples of the phenomenon. Moreover, we discuss recent data relating to the regulation of enzyme activity by compartmentalization into cytoophidia. Finally, we hypothesize potential roles for enzyme filament formation in the regulation of metabolism, development and disease.