Meningitis caused by lymphocytic choriomeningitis virus in a patient with leukemia
Meningitis caused by lymphocytic choriomeningitis virus in a patient with leukemia
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DOI：
10.1097/mph.0b013e318182e72b
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发表时间：
2008-10-01
影响因子：
1.2
通讯作者：
Rodriguez, Vilmarie
中科院分区：
文献类型：
--
作者：
Ai-Zein, Naser;Boyce, Thomas G.;Rodriguez, Vilmarie
我们报告一个15岁的女孩患有t细胞急性淋巴细胞白血病，她在接受维持化疗时出现发烧，中性粒细胞减少和严重头痛。脑脊液检查显示a淋巴细胞增多症，无白血病复发迹象。经血清学鉴定为淋巴细胞性脉络丛脑膜炎病毒所致脑膜炎。患者的病程因脑积水而复杂化，需要放置脑室腹腔分流器和颅内出血。淋巴细胞性脉络丛脑膜炎病毒是一种罕见的无菌性脑膜炎的原因，应考虑在症状性免疫功能低下的病人有适当的暴露史。
We report a case of 15-year-old girl with T-cell acute lymphoblastic leukemia who had fever, neutropenia, and severe headache while receiving maintenance chemotherapy. Cerebrospinal fluid testing revealed a. lymphocytic pleocytosis and no evidence of relapsed leukemia. Meningitis caused by lymphocytic choriomeningitis virus was identified serologically. The patient's course was complicated by hydrocephalus requiring ventriculoperitoneal shunt placement and by an intracranial hemorrhage. Lymphocytic choriomeningitis virus is a rare cause of aseptic meningitis that should be considered in the symptomatic immunocompromised patient with an appropriate exposure history.