Vibrissa Self-Motion and Touch Are Reliably Encoded along the Same Somatosensory Pathway from Brainstem through Thalamus
Vibrissa Self-Motion and Touch Are Reliably Encoded along the Same Somatosensory Pathway from Brainstem through Thalamus
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DOI：
10.1371/journal.pbio.1002253
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发表时间：
2015-09-01
期刊：
影响因子：
9.8
通讯作者：
Kleinfeld, David
中科院分区：
文献类型：
--
作者：
Moore, Jeffrey D.;Lindsay, Nicole Mercer;Kleinfeld, David
主动感知涉及内部产生的运动事件与外部感觉的融合。对于啮齿类动物，主动躯体感觉包括用触须扫描周围环境。在这样做时，触须可以在搅拌周期中以任何角度接触物体。触摸和触须自我运动的表征原则上可以沿着沿着单独的路径编码，或者共享从外周到皮层的单一路径。过去的研究表明，从感受器到皮层的丘系通路（包括三叉神经主核和丘脑腹后内侧核）的神经元沿着的尖峰频率基本上受到触摸的调制。与此相反，尖峰率沿着的三叉神经脊束通路，其中包括嘴侧脊神经间极，丘脑后内侧，腹侧三叉神经节核，只有微弱的调制触摸。在这里，我们发现，神经元沿着丘系通路鲁棒地编码有节奏的拂动在一个周期的基础上，而编码沿着丘系通路是相对较差的。因此，触摸和自我运动的表征共享一条路径。事实上，一些单独的神经元携带两种信号，因此具有超线性增益函数的上游神经元原则上可以解调这些信号，以恢复已知的触摸解码，作为拂动周期中触须位置的函数。
Active sensing involves the fusion of internally generated motor events with external sensation. For rodents, active somatosensation includes scanning the immediate environment with the mystacial vibrissae. In doing so, the vibrissae may touch an object at any angle in the whisk cycle. The representation of touch and vibrissa self-motion may in principle be encoded along separate pathways, or share a single pathway, from the periphery to cortex. Past studies established that the spike rates in neurons along the lemniscal pathway from receptors to cortex, which includes the principal trigeminal and ventral-posterior-medial thalamic nuclei, are substantially modulated by touch. In contrast, spike rates along the paralemniscal pathway, which includes the rostral spinal trigeminal interpolaris, posteromedial thalamic, and ventral zona incerta nuclei, are only weakly modulated by touch. Here we find that neurons along the lemniscal pathway robustly encode rhythmic whisking on a cycle-bycycle basis, while encoding along the paralemniscal pathway is relatively poor. Thus, the representations of both touch and self-motion share one pathway. In fact, some individual neurons carry both signals, so that upstream neurons with a supralinear gain function could, in principle, demodulate these signals to recover the known decoding of touch as a function of vibrissa position in the whisk cycle.