AGPS THROUGH TIME AND SPACE
AGPS THROUGH TIME AND SPACE
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DOI：
10.1002/9781119312994.apr0608
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发表时间：
2018-11-01
影响因子：
1.6
通讯作者：
Johnson, Kim
中科院分区：
文献类型：
--
作者：
Ma, Yingxuan;Zeng, Wei;Johnson, Kim
神秘的阿拉伯半乳聚糖蛋白（AGPs）几十年来一直吸引着研究人员。在20世纪60年代，由于它们的水溶性，AGP很容易从大量物种中提取。当时，研究主要集中在碳水化合物成分上，而蛋白质核心的存在在很大程度上是未知的。早在1965年就有人提到聚糖与含羟脯氨酸的蛋白质的结合，近10年后，从小麦中分离出一种阿拉伯半乳聚糖肽，最终表明蛋白质和聚糖的共价结合。另外50年的研究提供了对蛋白质骨架和聚糖结构的多样性的深入了解;它们在进化的“时间”和它们在质膜-细胞壁界面处占据的“空间”中的存在，结合组织特异性，可以具有重要的信号功能。本文重点介绍了最近的发展，使深入了解这个不同的家庭的进化，生物学作用和分子机制。
The enigmatic arabinogalactan-proteins (AGPs) have fascinated and challenged researchers for decades. In the 1960s, AGPs were being readily extracted from a large number of species due to their water solubility. At the time, research was focused on the carbohydrate component and the existence of protein core was largely unknown. The association of glycans with hydroxyproline-containing proteins was alluded to as early as 1965, and nearly 10 years later an arabinogalactan-peptide from wheat was isolated that conclusively showed the covalent association of protein and glycans. A further 50 years of research has provided insight into the diversity of the protein backbones and glycan structures; their presence across evolutionary 'time' and the 'space' they occupy at the plasma membrane-cell wall interface that, combined with tissue specificity, can have important signalling functions. This article highlights recent developments that are enabling insights into the evolution, biological roles, and molecular mechanisms of this diverse family.