Long-term neurobehavioural impact of the postnatal environment in rats: manipulations, effects and mediating mechanisms
Long-term neurobehavioural impact of the postnatal environment in rats: manipulations, effects and mediating mechanisms
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DOI：
10.1016/s0149-7634(03)00009-5
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发表时间：
2003-01-01
影响因子：
8.2
通讯作者：
Feldon, J
中科院分区：
文献类型：
--
作者：
Pryce, CR;Feldon, J
大鼠幼仔出生后环境的主要特征是其母亲和同窝仔。出生时发育不良的幼犬在这种环境中迅速成熟，并调节母犬和同窝仔的行为和生理，反之亦然。研究大鼠出生后环境对其长期神经行为发育的影响具有重要意义。事实上，它是一个主要的例子-在生物学，社会学和医学科学的接口-动物模型的研究环境和基因组之间的相互作用，在急性和慢性调节的表型。大鼠出生后环境的特定实验操作已被证明对成年期的神经生物学、生理学和行为表型产生强大而显著的影响。在本综述中，我们提出了一些主要的研究结果，包括一些原始数据，并讨论了这些现有的数据可以告诉我们的长期神经行为的影响，在大鼠出生后的环境，外部和内部的机制，介导这些影响，以及最合适的方向，为未来的基础和应用研究在这一领域。(C)2003爱思唯尔科技有限公司版权所有。
The major characteristics of the postnatal environment of the rat pup are its mother and littermates. The pup, which is poorly developed at birth, matures rapidly in this environment, and regulates the behaviour and physiology of the dam and littermates, as well as vice versa. The study of the impact of the rat's postnatal environment on its long-term neurobehavioural development is of fundamental importance. In fact, it is one of the major examples-at the interface of the biological, social and medical sciences-of animal models for the study of the interaction between the environment and the genome in both the acute and chronic regulation of the phenotype. Specific experimental manipulations of the rat postnatal environment have been demonstrated to exert robust and marked effects on neurobiological, physiological and behavioural phenotypes in adulthood. In the present review we present some of the major findings, including some original data, and discuss what these existing data can tell us about the long-term neurobehavioural effects of the postnatal environment in rats, the external and internal mechanisms that mediate these effects, and the most appropriate directions for future basic and applied research in this area. (C) 2003 Elsevier Science Ltd. All rights reserved.