Effect of Non-Surgical Periodontal Therapy on C-Reactive Protein, Oxidative Stress, and Matrix Metalloproteinase (MMP)-9 and MMP-2 Levels in Patients With Type 2 Diabetes: A Randomized Controlled Study
Effect of Non-Surgical Periodontal Therapy on C-Reactive Protein, Oxidative Stress, and Matrix Metalloproteinase (MMP)-9 and MMP-2 Levels in Patients With Type 2 Diabetes: A Randomized Controlled Study
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DOI：
10.1902/jop.2011.110148
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发表时间：
2012-01-01
影响因子：
4.3
通讯作者：
Madianos, Phoebus N.
中科院分区：
文献类型：
--
作者：
Koromantzos, Panagiotis A.;Makrilakis, Konstantinos;Madianos, Phoebus N.
背景资料：糖尿病（DM）患者的血糖控制受到全身炎症和氧化应激的影响。牙周治疗对这些全身因素的影响可能与血糖状态的改善有关。本研究的目的是评估6个月内非手术牙周治疗对2型糖尿病患者血清高敏C反应蛋白（hsCRP）、d-8-iso前列腺素F2 a（d-8-iso）（作为氧化应激标志物）以及基质金属蛋白酶（MMP）-2和MMP-9水平的影响。方法：将60名患有2型糖尿病和中重度牙周病的参与者随机分为干预组（IG）和对照组（CG）。IG接受洁治和根面平整，而CG在基线时接受龈上清洁，6个月时接受洁治和根面平整。在基线和1、3、6个月时对两组参与者进行评估。每次访视时记录的牙周数据包括探诊深度、临床附着丧失、探诊出血和牙龈指数。结果：hsCRP、d-8-iso、MMP-2、MMP-9有下降趋势，但无统计学意义。MMP-2水平保持不变后牙周treatment.Conclusion：有效的非手术牙周治疗的参与者与2型糖尿病和中度至重度牙周病改善显着A1 C水平，但没有导致在统计学上显着改善hsCRP，d-8-iso，MMP-2，MMP-9水平。牙周病学杂志2012;83：3-10.
Background: It is well accepted that glycemic control in patients with diabetes mellitus (DM) is affected by systemic inflammation and oxidative stress. The effect of periodontal therapy on these systemic factors may be related to improvement on glycemic status. The aim of the present study is to assess over a period of 6 months the effect of non-surgical periodontal therapy on serum levels of high-sensitivity C-reactive protein (hsCRP), d-8-iso prostaglandin F2a (d-8-iso) as a marker of oxidative stress, and matrix metalloproteinase (MMP)-2 and MMP-9 on patients with type 2 DM.Methods: Sixty participants with type 2 DM and moderate to severe periodontal disease were randomized into intervention (IG) and control (CG) groups. IG received scaling and root planing, whereas CG received supragingival cleaning at baseline and scaling and root planing at 6 months. Participants of both groups were evaluated at baseline and 1, 3, and 6 months. Periodontal data recorded at each visit included probing depth, clinical attachment loss, bleeding on probing, and gingival index. Blood was collected at each visit for the assay of serum glycated hemoglobin A1c (A1c), hsCRP, d-8-iso, MMP-2, and MMP-9.Results: Although there was a trend to a reduction in hsCRP, d-8-iso and MMP-9 it did not reach statistical significance. MMP-2 levels remained unchanged after periodontal treatment.Conclusion: Effective non-surgical periodontal treatment of participants with type 2 DM and moderate to severe periodontal disease improved significantly A1c levels but did not result in a statistically significant improvement in hsCRP, d-8-iso, MMP-2, and MMP-9 levels. J Periodontol 2012;83:3-10.