Absence of nystagmus during REM sleep in patients with vestibular neuritis
Absence of nystagmus during REM sleep in patients with vestibular neuritis
复制标题
前庭神经炎患者在快速眼动睡眠期间无眼球震颤
DOI：
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发表时间：
2001
影响因子：
11
通讯作者：
U. Büttner
中科院分区：
文献类型：
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作者：
I. Eisensehr;S. Noachtar;M. Strupp;H. v Lindeiner;T. Brandt;U. Büttner
眼跳，包括眼球震颤的快相，在嗜睡和非快速眼动(NREM)睡眠期间消失，但在警觉状态和REM睡眠期间出现。本研究的目的是确定前庭神经炎患者在快速眼动睡眠期间是否存在自发性眼球震颤。 对8例前庭神经炎引起的自发性眼球震颤患者和8例无眼球震颤的对照患者进行了至少一晚的多导睡眠监测。分析眼球震颤的快相。分别在入睡前3~5min的清醒状态、夜间睡眠的第一次REM发作和最后一次REM发作、夜间睡眠后清晨清醒状态下计算左右水平扫视次数。 所有前庭神经炎患者在多导睡眠图监测前、后清醒状态下，前庭病变对侧的眼跳(快相)明显增多。这反映了他们的自发眼球震颤。相比之下，在REM睡眠中，前庭神经炎患者在扫视方向上没有优势。REM患者和对照组的眼球运动模式相同。 总结，在快速眼动睡眠期间，清醒状态的前庭神经炎的外周前庭失衡导致眼球震颤在脑干水平不活跃。
Saccades, including fast phases of nystagmus, disappear during drowsiness and non-rapid eye movement (NREM) sleep, but are present during the alert state and REM sleep. The purpose of this study was to determine whether spontaneous nystagmus is present in patients with vestibular neuritis during REM sleep. Eight patients with spontaneous nystagmus due to vestibular neuritis and eight control patients without any nystagmus underwent at least one night of polysomnography. Fast phases of nystagmus were analyzed. The number of right and left horizontal saccades were counted, first during 3–5 minute samples of the awake state before sleep onset, then during the first REM episode and the last REM episode of nocturnal sleep, and finally during the alert state in the morning after nocturnal sleep. All patients with vestibular neuritis showed significantly more saccades (fast phases) towards the side contralateral to their vestibular lesion in the awake state before and after the polysomnography. This reflects their spontaneous nystagmus. By contrast, during REM sleep the patients with vestibular neuritis showed no preponderance in saccade direction. The eye movement pattern in REM was the same for patients and controls. In conclusion, peripheral vestibular imbalance producing nystagmus in vestibular neuritis in the awake state is not active at the brain stem level during REM sleep.