The impact of lipid-lowering medications on coronary artery plaque characteristics.
The impact of lipid-lowering medications on coronary artery plaque characteristics.
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DOI：
10.1016/j.ajpc.2021.100294
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发表时间：
2021-12
影响因子：
4.1
通讯作者：
Alenghat FJ
中科院分区：
文献类型：
--
作者：
Pulipati VP;Alenghat FJ
动脉粥样硬化是冠状动脉疾病的主要原因。在过去的几十年里，降脂治疗取得了重大进展，这是动脉粥样硬化性心血管疾病预防的核心组成部分。除了通过血脂异常管理降低心血管风险外，一些基于脂质的治疗通过控制脂质积聚、斑块稳定性、局部炎症、内皮功能障碍和血栓形成的机制在动脉粥样硬化斑块本身水平显示出前景。降脂治疗改变动脉粥样硬化斑块负荷、大小、组成和易损性的能力应与其减缓疾病进展的能力相关。这篇综述讨论了斑块的特点，诊断模式，以评估这些特点，以及他们是如何改变目前和新兴的降脂治疗，所有在人类冠状动脉疾病。
Atherosclerosis is the predominant cause of coronary artery disease. The last several decades have witnessed significant advances in lipid-lowering therapies, which comprise a central component of atherosclerotic cardiovascular disease prevention. In addition to cardiovascular risk reduction with dyslipidemia management, some lipid-based therapies show promise at the level of the atherosclerotic plaque itself through mechanisms governing lipid accumulation, plaque stability, local inflammation, endothelial dysfunction, and thrombogenicity. The capacity of lipid-lowering therapies to modify atherosclerotic plaque burden, size, composition, and vulnerability should correlate with their ability to reduce disease progression. This review discusses plaque characteristics, diagnostic modalities to evaluate these characteristics, and how they are altered by current and emerging lipid-lowering therapies, all in human coronary artery disease.
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影响因子：
4
作者：
Gibson MS;Domingues N;Vieira OV
通讯作者：
Vieira OV
影响因子：
9.3
作者：
Banach M;Serban C;Sahebkar A;Mikhailidis DP;Ursoniu S;Ray KK;Rysz J;Toth PP;Muntner P;Mosteoru S;García-García HM;Hovingh GK;Kastelein JJ;Serruys PW;Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group
通讯作者：
Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group
影响因子：
2.8
作者：
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通讯作者：
Kashyap, Moti L.
影响因子：
14
作者：
Hattori, Kousuke;Ozaki, Yukio;Narula, Jagat
通讯作者：
Narula, Jagat
影响因子：
14
作者：
Hamdan, Ashraf;Asbach, Patrick;Fleck, Eckart
通讯作者：
Fleck, Eckart