The role of dopamine in maintaining intracranial self-stimulation in the ventral tegmentum, nucleus accumbens, and medial prefrontal cortex.
The role of dopamine in maintaining intracranial self-stimulation in the ventral tegmentum, nucleus accumbens, and medial prefrontal cortex.
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多巴胺在维持腹侧被盖、伏核和内侧前额皮质颅内自我刺激中的作用。
DOI：
10.1037/h0081676
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
H. Fibiger
中科院分区：
文献类型：
--
作者：
A. Phillips;H. Fibiger
在雄性白化Wistar大鼠的腹侧被盖和伏隔核或内侧前额叶皮层分别植入2个慢性双极电极。一旦中脑和前脑电极都激发了稳定的颅内自我刺激，6-羟多巴胺损伤被置于下丘脑外侧奖励电极之间的上升多巴胺能通路中。数据表明，多巴胺在腹侧被盖的自我刺激中起着重要作用，并有助于前额叶皮层的这种行为。研究结果还表明，非多巴胺能系统有助于大脑刺激奖励现象。（法语摘要）（28 ref）（PsycInfo Database Record (c) 2022 APA，版权所有）
Male albino Wistar rats were prepared with 2 chronic bipolar electrodes implanted ipsilaterally in the ventral tegmentum and either the nucleus accumbens or the medial prefrontal cortex. Once stable intracranial self-stimulation was elicited from both midbrain and forebrain electrodes, 6-hydroxydopamine lesions were placed into the ascending dopaminergic pathways between the rewarding electrode placements at the level of the lateral hypothalamus. Data suggest that dopamine plays an important role in self-stimulation in the ventral tegmentum and contributes to this behavior in the prefrontal cortex. Findings also show that nondopaminergic systems contribute to the phenomenon of brain-stimulation reward.(French summary)(28 ref)(PsycInfo Database Record (c) 2022 APA, all rights reserved)