Peri-Selective Direct Acylmethylation and Amidation of Naphthalene Derivatives Using Iridium and Rhodium Catalysts
Peri-Selective Direct Acylmethylation and Amidation of Naphthalene Derivatives Using Iridium and Rhodium Catalysts
复制标题
DOI：
10.1055/a-1472-1059
复制
发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Yuji Nishii;M. Miura;C. Kona;Rikuto Oku
中科院分区：
文献类型：
--
作者：
Yuji Nishii;M. Miura;C. Kona;Rikuto Oku
摘要本文报道了铱催化的萘衍生物的酰基甲基化反应和铑催化的酰胺化反应。使用SMe基团作为导向基团是确保近选择性官能化的关键，并且它可以在催化后容易地去除或二次转化为其他合成有用的官能团。
Abstract An iridium-catalyzed acylmethylation and a rhodium-catalyzed amidation of naphthalene derivatives are reported, adopting sulfoxonium ylides and dioxazolones as carbene and nitrene transfer agents, respectively. The use of SMe group as a directing group was key to ensure the peri-selective functionalization, and it can be easily removed or diversely transformed to other synthetically useful functionalities after the catalysis.