Bragg peak proton beam therapy for arteriovenous malformation of the brain.
Bragg peak proton beam therapy for arteriovenous malformation of the brain.
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布拉格峰质子束治疗脑动静脉畸形。
DOI：
10.1093/neurosurgery/31.cn_suppl_1.248
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
R. Adams
中科院分区：
文献类型：
--
作者：
R. Kjellberg;K. Davis;S. Lyons;W. Butler;R. Adams
摘要脑动静脉畸形患者，易发生致残性或致命性复发性出血、癫痫发作、严重头痛和进行性神经功能缺损，通常由于病变的位置、大小或手术风险，可能被认为不适合常规治疗（开颅切除或栓塞）。我们用立体定向布拉格峰质子束疗法治疗了这些患者，并报告了治疗后2至16年随访的74例。质子束治疗旨在诱导胶原蛋白和透明物质的内皮下沉积，在手术后的前12至24个月内使小血管的管腔变窄并使畸形的壁变厚。在治疗后的前12个月内发生了2例出血死亡，但在此间隔后没有发生致命或致残性出血。在大多数情况下，癫痫发作、头痛和进行性神经功能缺损被阻止或改善。Bragg-peak proto.
Abstract Patients with arteriovenous malformations of the brain, who are subject to disabling or fatal recurrent hemorrhage, seizures, severe headache, and progressive neurologic deficits, may be considered unsuitable for conventional therapies (craniotomy with excision or embolization), usually because of the location, size, or operative risk of the lesion. We have treated such patients with stereotactic Bragg-peak proton-beam therapy and report the follow-up of 74 of the first 75, 2 to 16 years after treatment. Proton-beam therapy is intended to induce subendothelial deposition of collagen and hyaline substance, which narrows the lumens of small vessels and thickens the walls of the malformation during the first 12 to 24 months after the procedure. Two deaths from hemorrhage occurred in the first 12 months after treatment, but no lethal or disabling hemorrhages occurred after this interval. Seizures, headaches, and progressive neurologic deficits were in most cases arrested or improved. Bragg-peak proto...