Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs
Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs
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DOI：
10.1016/j.humpath.2006.06.026
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发表时间：
2007-01-01
期刊：
影响因子：
3.3
通讯作者：
Mok, Samuel C.
中科院分区：
文献类型：
--
作者：
Nishimura, Sadako;Tsuda, Hiroshi;Mok, Samuel C.
以前，我们报道ABCF 2蛋白在透明细胞中的表达高于浆液性组织型卵巢腺癌，并且其表达与透明细胞卵巢癌患者的化疗反应相关。在这项研究中，我们研究了ABCF 2蛋白在粘液性，类粘液性和低分化型卵巢腺癌中的表达。此外，ABCF 2表达在来自不同器官的透明细胞腺癌中进行了评估。本研究共包括335例卵巢上皮癌、23例子宫体透明细胞腺癌和34例肾透明细胞腺癌。免疫组化法检测ABCF 2蛋白表达。结果显示，透明细胞型卵巢癌组织中ABCF 2的胞浆表达显著高于其他类型（P
Previously, we reported that ABCF2 protein expression is higher in clear cell than serous histotype of ovarian adenocarcinomas and that its expression correlates with chemoresponse in patients with clear cell ovarian cancer. In this study, we examined ABCF2 protein expression in mucinous, endometrioid, and poorly differentiated type of ovarian adenocarcinomas. In addition, ABCF2 expression was evaluated in clear cell adenocarcinomas derived from different organs. A total of 335 epithelial ovarian cancers, 23 clear cell adenocarcinomas of uterine corpus, and 34 clear cell adenocarcinotmas of kidney were included in this study. ABCF2 protein expression was determined by immunohistochemistry. The results showed that cytoplasmic ABCF2 expression was significantly higher in clear cell-type ovarian cancer specimens compared with other types (P