Evidence for positive epistasis in HIV-1
Evidence for positive epistasis in HIV-1
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DOI：
10.1126/science.1101786
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发表时间：
2004-11-26
期刊：
影响因子：
56.9
通讯作者：
Petropoulos, CJ
中科院分区：
文献类型：
--
作者：
Bonhoeffer, S;Chappey, C;Petropoulos, CJ
生殖策略，如有性生殖和重组，涉及父母的基因组改组产生后代是普遍存在的性质。然而，它们的进化益处仍不清楚。许多理论已经确定了潜在的好处，但相关数据的稀缺阻碍了进展。一类理论是基于影响适应性的突变表现出负上位性的假设。逆转录病毒经常重组，因此提供了一个独特的机会来测试这些理论。使用9466人类免疫缺陷病毒1型（HIV-1）分离株的氨基酸序列数据和适应度值，我们发现这些理论相反，强有力的统计证据，阳性上位性在HIV-1的优势。
Reproductive strategies such as sexual reproduction and recombination that involve the shuffling of parental genomes for the production of offspring are ubiquitous in nature. However, their evolutionary benefit remains unclear. Many theories have identified potential benefits, but progress is hampered by the scarcity of relevant data. One class of theories is based on the assumption that mutations affecting fitness exhibit negative epistasis. Retroviruses recombine frequently and thus provide a unique opportunity to test these theories. Using amino acid sequence data and fitness values from 9466 human immunodeficiency virus 1 (HIV-1) isolates, we find in contrast to these theories strong statistical evidence for a predominance of positive epistasis in HIV-1.