The transformation of hormonal stress responses throughout puberty and adolescence
The transformation of hormonal stress responses throughout puberty and adolescence
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DOI：
10.1530/joe-11-0206
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发表时间：
2011-09-01
影响因子：
4
通讯作者：
Romeo, Russell D.
中科院分区：
文献类型：
--
作者：
Foilb, Allison R.;Lui, Patina;Romeo, Russell D.
与成年人相比，青春期前的大鼠表现出更高的激素应激反应性，因为在急性应激源后，促肾上腺皮质激素和皮质酮水平需要两倍的时间（即 40-60 分钟）才能恢复到基线。尽管压力反应性发生了巨大变化，并且青春期发育的关键性质，但从青春期开始到成年期间激素压力反应的成熟尚未得到彻底研究。为了检验这一点，我们测量了 30 天、40 天、50 天、60 天和 70 天（即跨越青春期和青春期发育）雄性大鼠在 30 分钟的束缚应激前后的 ACTH、皮质酮和睾酮水平。我们发现，类似成人的 ACTH 应激反应在 50 至 60 天龄之间出现，而皮质酮反应在 30 至 40 天龄之间发生变化。我们还发现，肾上腺皮质酮浓度与约束后的血浆皮质酮反应平行，这表明在青少年发育过程中，压力诱导的肾上腺皮质酮合成减少，并且可能至少部分导致青春期前后观察到的差异应激反应。最后，压力会导致睾酮分泌增加，但仅限于 50 天后。总的来说，这些结果表明，荷尔蒙应激反应的变化发生在整个青少年成熟过程中，并且这些反应表现出不同的发育特征。内分泌学杂志 (2011) 210, 391-398
Prepubertal rats display heightened hormonal stress reactivity compared with adults in that levels of ACTH and corticosterone take twice as long (i.e. 40-60 min) to return to baseline following an acute stressor. Despite this substantial change in stress responsiveness, and the critical nature of the adolescence period of development, the maturation of the hormonal stress response from the time of pubertal onset to adulthood has not been thoroughly investigated. To examine this, we measured ACTH, corticosterone, and testosterone in 30-, 40-, 50-, 60-, and 70-day-old (i.e. spanning pubertal and adolescent development) male rats before and after a 30 min session of restraint stress. We found that the adult-like ACTH stress response develops between 50 and 60 days of age, while the corticosterone response changes between 30 and 40 days of age. We also found that adrenal corticosterone concentrations paralleled the plasma corticosterone response following restraint, suggesting that stress-induced adrenal corticosterone synthesis decreases during adolescent development and may, at least in part, contribute to the differential stress response observed before and after puberty. Finally, stress leads to increases in testosterone secretion, but only after 50 days of age. Collectively, these results indicate that shifts in hormonal stress responses occur throughout adolescent maturation and that these responses show distinct developmental profiles. Journal of Endocrinology (2011) 210, 391-398