Protective role of vitamin D signaling in skin cancer formation.
Protective role of vitamin D signaling in skin cancer formation.
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DOI：
10.1016/j.jsbmb.2012.09.021
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发表时间：
2013-07
影响因子：
4.1
通讯作者：
Teichert, Arnaud
中科院分区：
文献类型：
--
作者：
Bikle, Daniel D.;Elalieh, Hashem;Welsh, JoEllen;Oh, Dennis;Cleaver, James;Teichert, Arnaud
在临床上，维生素D充足与许多组织对恶性肿瘤的保护有关，来自动物和细胞培养研究的大量证据支持这种保护作用。然而，皮肤癌的不同之处在于，较高的血清25OHD水平与基底细胞癌(BCC)的增加有关，基底细胞癌是最常见的表皮恶性肿瘤形式。这一结果可能被解释为表明UVR(光谱280-320)在皮肤中产生维生素D的作用以及导致导致表皮恶性肿瘤的DNA突变和增殖性变化。最近的动物研究表明，缺乏维生素D受体(VDR)的小鼠容易因化学致癌物如7，12二甲基苯并菲(DMBA)或慢性UVR暴露而患上皮肤肿瘤。这些研究表明，皮肤中维生素D的产生和随后通过VDR发出的信号可能在一定程度上进化为一种保护机制，以防止UVR诱导的表皮癌症的形成。在这篇手稿中，我们提供的证据表明，维生素D信号通过控制角质形成细胞的增殖和分化，促进DNA修复，并抑制UVR暴露后Hhedgehog(HH)途径的激活来保护皮肤免受癌症形成。
Vitamin D sufficiency is associated with protection against malignancy in a number of tissues clinically, and a strong body of evidence from animal and cell culture studies supports this protective role. Cancers in the skin differ, however, in that higher serum levels of 25OHD are associated with increased basal cell carcinomas (BCC), the most common form of epidermal malignancy. This result may be interpreted as indicating the role of UVR (spectrum 280–320) in producing vitamin D in the skin as well as causing those DNA mutations and proliferative changes that lead to epidermal malignancies. Recent animal studies have shown that mice lacking the vitamin D receptor (VDR) are predisposed to developing skin tumors either from chemical carcinogens such as 7,12 dimethylbenzanthracene (DMBA) or chronic UVR exposure. Such studies suggest that vitamin D production and subsequent signaling through the VDR in the skin may have evolved in part as a protective mechanism against UVR induced epidermal cancer formation. In this manuscript we provide evidence indicating that vitamin D signaling protects the skin from cancer formation by controlling keratinocyte proliferation and differentiation, facilitating DNA repair, and suppressing activation of the hedgehog (Hh) pathway following UVR exposure.
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影响因子：
64.8
作者：
Bartkova, Jirina;Rezaei, Nousin;Gorgoulis, Vassilis G.
通讯作者：
Gorgoulis, Vassilis G.
影响因子：
3.3
作者：
Dixon, Katie M.;Norman, Anthony W.;Mason, Rebecca S.
通讯作者：
Mason, Rebecca S.
影响因子：
6.5
作者：
Ellison, Tara I.;Smith, Molly K.;MacDonald, Paul N.
通讯作者：
MacDonald, Paul N.
影响因子：
6.5
作者：
Bonifas, JM;Pennypacker, S;Epstein, EH
通讯作者：
Epstein, EH
DOI：
10.1073/pnas.0607057103
发表时间：
2006-11-28
影响因子：
11.1
作者：
Bielas, Jason H.;Loeb, Keith R.;Loeb, Lawrence A.
通讯作者：
Loeb, Lawrence A.