Survey of the susceptibility of urinary isolates to antibacterial agents in 2003
Survey of the susceptibility of urinary isolates to antibacterial agents in 2003
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DOI：
10.1007/s10156-004-0356-9
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发表时间：
2005-02-01
影响因子：
2.2
通讯作者：
Hoshinaga, Kiyotaka
中科院分区：
文献类型：
--
作者：
Ishikawa, Kiyohito;Hayakawa, Satoshi;Hoshinaga, Kiyotaka
在2003年，826尿路致病菌株从我们的病人的尿液中获得。我们根据美国国家临床标准委员会（NCCLS）推荐的最小抑菌浓度（MIC）折点评估了它们对抗菌药物的活性。耐甲氧西林菌株占金黄色葡萄球菌和表皮葡萄球菌的70%左右。最常见的革兰氏阳性菌为粪肠球菌（15.6%）。屎肠球菌对β-内酰胺类抗生素、氟喹诺酮类抗生素和四环素类抗生素的耐药率分别为0%、6%和<18%。革兰阴性杆菌中大肠埃希菌占50%以上。耐药或中间型菌株占20%以上，其中4株（1.1%）疑似产超广谱β-内酰胺酶（ESBL）。所有产ESBLs菌株均对FQs耐药。超过95%的肺炎克雷伯菌对所有药物敏感。对铜绿假单胞菌的抗菌活性分布表明，多重耐药菌株的数量减少，对所有药物敏感的菌株增加。不同种变形杆菌对抗菌药物的耐药性存在一定差异。从粘质沙雷菌中未分离到产ESBL或多重耐药菌株。本次调查表明，严重的临床问题将导致越来越多的革兰氏阳性球菌中的多重耐药肠球菌菌种，革兰氏阴性杆菌中的产ESBL菌株或耐药菌株的分离。
In 2003, 826 uropathogenic strains were obtained from the urine of our patients. We assessed their activities to antibacterial agents based on the minimal inhibitory concentration (MIC) breakpoints recommended by the National Committee for Clinical Standards (NCCLS). Methicillin-resistant strains accounted for about 70% of Staphylococcus aureus and Staphylococcus epidermidis. The most common gram-positive species was Enterococcus faecalis (15.6%). Enterococcus faecium was the most resistant of the enterococcal species, and the rate of susceptibility to beta-lactams (BLs), fluoroquinolones (FQs), and tetracyclines (TCs) was 0%, 6%, and less than 18%, respectively. Escherichia coli accounted for over 50% of the gram-negative bacilli. The proportion of FQ-resistant or intermediate strains was over 20%, and four of these strains (1.1%) were suspected of producing extended-spectrum beta-lactamase (ESBL). All the ESBL-producing strains (ESBLs) possess resistance to FQs. Over 95% of Klebsiella pneumoniae was susceptible to all agents. The distribution of antimicrobial activity against Pseudomonas aeruginosa indicated a decrease in the number of multidrug-resistant strains and an increase in strains susceptible to all agents. Some differences existed in the resistance to antibacterial agents among Proteus species. No ESBL-producing or multidrug-resistant strain was isolated from Serratia marcescens. This survey suggests that serious clinical problems will result from the increasing number of enterococcal species with multidrug resistance in gram-positive cocci, and isolates of ESBL-producing or FQs-resistant strains in gram-negative bacilli.