Temporal and spatial appearance of the membrane cytoskeleton and perineuronal nets in the rat neocortex
Temporal and spatial appearance of the membrane cytoskeleton and perineuronal nets in the rat neocortex
复制标题
大鼠新皮质膜细胞骨架和神经周围网的时间和空间外观
DOI：
10.1016/0304-3940(96)12643-4
复制
发表时间：
1996
影响因子：
2.5
通讯作者：
M. Celio
中科院分区：
文献类型：
--
作者：
E. Wintergerst;D. Weisenhorn;F. Rathjen;B. Riederer;S. Lambert;M. Celio
小白蛋白免疫反应性中间神经元被神经元周围网包围，其中含有细胞外基质分子（例如腱蛋白-R）。此外，它们似乎具有特殊的细胞骨架，其中包括锚蛋白R和βR影蛋白。在目前的发育研究中，我们发现细胞内标记物小白蛋白、锚蛋白R和βR血影蛋白绒毛凝集素（一种神经周围网的细胞外标记物）出现在出生后第二周。出生后第三周，锚蛋白R和βR血影蛋白存在于小白蛋白阳性中间神经元中。 Tenascin-R 的拓扑分布与细胞内标记物相似。成人模式在产后第四周结束时建立。我们的结果表明，细胞骨架成熟可能是细胞外基质神经周围网组织的先决条件。
Parvalbumin-immunoreactive interneurons are surrounded by perineuronal nets, containing molecules of the extracellular matrix (e.g. tenascin-R). Furthermore, they seem to have a special cytoskeleton composed of, among others, ankyrinRand βRspectrin. In the present developmental study we showed that the intracellular markers parvalbumin, ankyrinRand βRspectrin Villosa agglutinin, an extracellular marker for perineuronal nets, appeared in the second postnatal week. In the third postnatal week, ankyrinRand βRspectrin were present in the parvalbumin-positive interneurons. Tenascin-R appeared in a similar topographic distribution as the intracellular markers. The adult pattern was established upon the end of the fourth postnatal week. Our results indicate that cytoskeletal maturity maybe a prerequisite for the organization of perineuronal nets of extracellular matrix.