Synthesis and biological evaluation of DNA targeting flexible side-chain substituted β-carboline derivatives
Synthesis and biological evaluation of DNA targeting flexible side-chain substituted β-carboline derivatives
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DOI：
10.1016/s0960-894x(00)00679-x
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发表时间：
2001-02-26
影响因子：
2.7
通讯作者：
Yang, M
中科院分区：
文献类型：
--
作者：
Xiao, SL;Lin, W;Yang, M
以L色氨酸为原料合成了一系列3-取代-β-咔啉衍生物。研究了这些化合物与DNA的插层结合方式、柔性烷基胺侧链对其插层能力和抗肿瘤活性的影响，与分子模拟结果吻合较好。(C)2001爱思唯尔科学有限公司。保留所有权利。
A series of 3-substituted-beta -carboline derivatives was synthesized from L-tryptophan. The intercalating binding mode of these compounds with DNA, the effects of the flexible alkylamine side chain on the intercalating ability and their antitumor activity were studied, which agreed well with the molecular modeling results. (C) 2001 Elsevier Science Ltd. All rights reserved.