Sessile adenoma of the gallbladder. Reappraisal of its importance as a precancerous lesion.
Sessile adenoma of the gallbladder. Reappraisal of its importance as a precancerous lesion.
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胆囊无蒂腺瘤。
DOI：
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发表时间：
1985
影响因子：
4.6
通讯作者：
K. Doi
中科院分区：
文献类型：
--
作者：
H. Sato;M. Mizushima;J. Ito;K. Doi
在解剖显微镜下检查了三百个胆石症患者的胆囊。十六人（5%）被发现患有所谓的无蒂腺瘤。它们由增生性衬里上皮和化生性粘液腺的混合物组成，其间质通常包括平滑肌纤维。 19% 的腺瘤病例中存在中度严重细胞异型性的小病灶，但没有一个有明确的恶性肿瘤证据。 31% 的病例在伴有或不伴有细胞异型性的增生性衬里上皮中发现癌胚抗原。无蒂腺瘤很可能代表反应性过度生长，因此我们更喜欢将其称为增生性息肉。
Three hundred gallbladders from patients with cholelithiasis were examined under a dissection microscope. Sixteen (5%) were found to have what have been called sessile adenomas. They consisted of mixtures of hyperplastic lining epithelium and metaplastic mucous glands, and their interstitium often included smooth-muscle fibers. Small foci of moderately severe cellular atypism were present in 19% of the adenoma cases, but none had definitive evidence of malignancy. Carcinoembryonic antigen was demonstrated in hyperplastic lining epithelium with or without cellular atypism in 31% of the cases. Sessile adenomas most likely represent reactive overgrowth and therefore we prefer to term them hyperplastic polyps.