Targeting RNA N(6)-methyladenosine modification: a precise weapon in overcoming tumor immune escape.
Targeting RNA N(6)-methyladenosine modification: a precise weapon in overcoming tumor immune escape.
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靶向RNA N6-甲基腺苷修饰：克服肿瘤免疫逃逸的精准武器
DOI：
10.1186/s12943-022-01652-3
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发表时间：
2022-09-07
期刊：
影响因子：
37.3
通讯作者：
Pang, Da
中科院分区：
文献类型：
--
作者：
Li, Wei;Hao, Yi;Zhang, Xingda;Xu, Shouping;Pang, Da
免疫疗法，特别是免疫检查点抑制物(ICIS)，已经彻底改变了许多类型癌症的治疗方法，特别是晚期癌症。然而，尽管有一部分患者在ICIS治疗后经历了戏剧性和长期的疾病消退，但大多数患者并没有从这些治疗中受益。有些人甚至可能经历癌症的进展。肿瘤细胞的免疫逃逸可能是这种低应答率的关键原因。N6-甲基腺苷(M6A)是最常见的RNA甲基化类型，被认为是肿瘤和免疫系统的关键调节因子。因此，M6A修饰及其相关调控因子是提高肿瘤免疫治疗效果的有希望的靶点。然而，M6A修饰与肿瘤免疫逃逸(TIE)之间的关系还没有得到全面的总结。因此，本文就TIE涉及的m6A修饰及其可能的作用机制的现有知识进行综述。此外，我们提供了目前可用的针对M6A调节器的药物的概述，这些药物已被测试其对TIE的升高效应。这篇综述建立了M6A修饰和TIE之间的联系，并通过特别针对TIE中涉及的M6A修饰，为最大化免疫治疗的疗效提供了新的见解和策略。
Immunotherapy, especially immune checkpoint inhibitors (ICIs), has revolutionized the treatment of many types of cancer, particularly advanced-stage cancers. Nevertheless, although a subset of patients experiences dramatic and long-term disease regression in response to ICIs, most patients do not benefit from these treatments. Some may even experience cancer progression. Immune escape by tumor cells may be a key reason for this low response rate. N6-methyladenosine (m6A) is the most common type of RNA methylation and has been recognized as a critical regulator of tumors and the immune system. Therefore, m6A modification and related regulators are promising targets for improving the efficacy of tumor immunotherapy. However, the association between m6A modification and tumor immune escape (TIE) has not been comprehensively summarized. Therefore, this review summarizes the existing knowledge regarding m6A modifications involved in TIE and their potential mechanisms of action. Moreover, we provide an overview of currently available agents targeting m6A regulators that have been tested for their elevated effects on TIE. This review establishes the association between m6A modifications and TIE and provides new insights and strategies for maximizing the efficacy of immunotherapy by specifically targeting m6A modifications involved in TIE.
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影响因子：
29.4
作者：
Chen, Huarong;Gao, Shanshan;Yu, Jun
通讯作者：
Yu, Jun
影响因子：
5
作者：
Cockova, Zuzana;Honc, Ondrej;Novotny, Jiri
通讯作者：
Novotny, Jiri
人RNAN⁶-甲基杜氏丁基脱甲基酶AlkBH5的结构提供了有关其核酸识别和脱甲基化机制的见解。
影响因子：
14.9
作者：
Aik W;Scotti JS;Choi H;Gong L;Demetriades M;Schofield CJ;McDonough MA
通讯作者：
McDonough MA
DOI：
10.1261/rna.065219.117
发表时间：
2018-03
期刊：
RNA (New York, N.Y.)
影响因子：
--
作者：
Darnell RB;Ke S;Darnell JE Jr
通讯作者：
Darnell JE Jr
影响因子：
32.4
作者：
Bonavita E;Bromley CP;Jonsson G;Pelly VS;Sahoo S;Walwyn-Brown K;Mensurado S;Moeini A;Flanagan E;Bell CR;Chiang SC;Chikkanna-Gowda CP;Rogers N;Silva-Santos B;Jaillon S;Mantovani A;Reis e Sousa C;Guerra N;Davis DM;Zelenay S
通讯作者：
Zelenay S