Field efficacy of recombinant R7 vaccine against chicken leucocytozoonosis
Field efficacy of recombinant R7 vaccine against chicken leucocytozoonosis
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DOI：
10.1292/jvms.66.483
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发表时间：
2004-05-01
影响因子：
1.2
通讯作者：
Gotanda, T
中科院分区：
文献类型：
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作者：
Ito, A;Gotanda, T
以卡氏住白细胞原虫第二代裂殖体（2GS）为抗原的重组R7蛋白（rR 7）疫苗在田间条件下对鸡白细胞原虫病的有效性进行了验证。用油佐剂rR 7疫苗（O-rR 7）对每年发生白细胞体病的鸡场饲养的鸡进行免疫，一次免疫即可产生高水平的抗2GS抗体。注射后观察到白细胞体病。在流行期间，出现了排绿色便、贫血、寄生虫血症等独特的临床症状，但O-rR 7免疫组鸡的症状明显轻于对照组（P
Effectiveness of vaccine that used recombinant R7 protein (rR7) as antigen that is derived from second-generation schizont (2GS) of Leucocytozoon caulleryi was verified under a field condition against chicken leucocytozoonosis. Chickens reared in a poultry farm where the chickens are attacked by leucocytozoonosis in every year were inoculated with oil-adjuvanted rR7 vaccine (O-rR7), and the immunized chickens were found to have production of antibodies against 2GS at a high level by one shot. Leucocytozoonosis was observed at post-injection. During the epidemic period of leucocytozoonosis, the unique clinical signs of the disease such as discharge of green feces and anemia, and also parasitemia were observed, however, compared to chickens in control group, those in O-rR7 vaccinated group had significantly slight symptoms (P