ADVERSE METABOLIC EFFECT OF OMEGA-3 FATTY-ACIDS IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS
ADVERSE METABOLIC EFFECT OF OMEGA-3 FATTY-ACIDS IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS
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DOI：
10.7326/0003-4819-108-5-663
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发表时间：
1988-05-01
影响因子：
39.2
通讯作者：
BRECHTEL, G
中科院分区：
文献类型：
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作者：
GLAUBER, H;WALLACE, P;BRECHTEL, G
对使用omega-3脂肪酸的兴趣增加，使我们在6名II型（非胰岛素依赖型）糖尿病患者中检查了它们的代谢作用。在饮食中添加这些脂肪酸1个月后，患者的空腹血糖从13.1 +-升高。1.3至15.3 .+-。1.3 mmol/L （P=0.03）和混合餐时葡萄糖面积增加22% （P=0.04）。基础肝糖输出量从97 .+-上升。9到122 .+-。8mg /m2 .cntdot。min (P=0.004)，而正糖钳法测定的葡萄糖处置率没有变化。空腹胰岛素水平相似；进食或静脉注射胰高血糖素刺激的胰岛素峰值水平分别下降了30%和39%。血浆和红细胞中omega-3脂肪酸含量显著升高。停用omega-3脂肪酸后，空腹血糖恢复到基线水平。2型糖尿病的Omega-3脂肪酸治疗导致快速但可逆的代谢恶化，肝基础糖输出量升高，胰岛素分泌受损，但葡萄糖处理率不变。在向II型糖尿病患者推荐omega-3脂肪酸时应谨慎使用。
Increased interest in using omega-3 fatty acids led us to examine their metabolic effects in six men with type II (non-insulin-dependent) diabetes mellitus. After 1 month of a diet supplemented with these fatty acids, the patients'' fasting glucose rose from 13.1 .+-. 1.3 to 15.3 .+-. 1.3 mmol/L (P=0.03) and glucose area duing a mixed meal profile rose by 22% (P=0.04). Basal hepatic glucose output rose from 97 .+-. 9 to 122 .+-. 8 mg/m2 .cntdot. min (P=0.004) but glucose disposal rates measured by euglycemic glucose clamp were unchanged. Fasting insulin levels were similar; peak insulin levels stimulated by meals or intravenous glucagon fell by 30% and 39%, respectively. Plasma and erythrocyte content of omega-3 fatty acid arose significantly. After omega-3 fatty acid withdrawal, fasting glucose returned to baseline. Omega-3 fatty acid treatment in type II diabetes leads to rapid but reversible metabolic deterioration, with elevated basal hepatic glucose output and impaired insulin secretion but unchanged glucose disposal rates. Caution should be used when recommending omega-3 fatty acids in type II diabetic persons.