Autoresuscitation: a survival mechanism in piglets.
Autoresuscitation: a survival mechanism in piglets.
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自动复苏：仔猪的一种生存机制。
DOI：
10.1152/jappl.1992.73.2.749
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Haddad,GG
中科院分区：
文献类型：
--
作者：
Sanocka,UM;Donnelly,DF;Haddad,GG
对仔猪进行研究，以确定1）长时间喉诱导呼吸抑制的心血管和神经生理学效应（n = 7）和2）这些效应是否受自主神经阻滞的调节（n = 6）。记录呼吸、心电图、脑电图（EEG）和血压，并测量血气。在轻度麻醉的情况下进行连续喉部刺激期间，每隔1-2.5分钟通过2 - 6次呼吸的集群中断呼吸暂停。与对照组相比，这些呼吸具有显著更大的潮气量（对照组的430 +/- 30%）、更短的吸气时间（87 +/- 5%）和更长的呼气时间（124 +/- 15%），因此具有喘息性质。随着每一组喘息，动脉PO 2从15 +/- 2增加到56 +/- 5 Torr，心率从84 +/- 7增加到161 +/- 5次/分钟，平均血压从48 +/- 4增加到106 +/- 6 mmHg。EEG在呼吸暂停发作后1分钟变得平坦，并且在整个刺激期间保持等电。周期性喘息不受交感神经或副交感神经阻滞的影响。这些数据表明，尽管EEG沉默，小猪可以通过启动喘息，不依赖于自主完整性的自动复苏。这些喘息明显改善心血管状态，并可能维持动物很长一段时间。
Piglets were studied to determine 1) the cardiovascular and neurophysiological effects of prolonged laryngeal-induced respiratory inhibition (n = 7) and 2) whether these effects were modulated by autonomic blockade (n = 6). Respiration, electrocardiogram, electroencephalogram (EEG), and blood pressure were recorded, and blood gases were measured. During continuous laryngeal stimulation in the presence of light anesthesia, apnea was interrupted every 1–2.5 min by clusters of two to six breaths. Compared with control, these breaths had a significantly greater tidal volume (430 +/- 30% of control), shorter inspiratory time (87 +/- 5%), and longer expiratory time (124 +/- 15%) and, thus, were of a gasping nature. With each cluster of gasps, arterial PO2 increased from 15 +/- 2 to 56 +/- 5 Torr, heart rate from 84 +/- 7 to 161 +/- 5 beats/min, and mean blood pressure from 48 +/- 4 to 106 +/- 6 mmHg. The EEG became flat by 1 min after the onset of apnea and remained isoelectric throughout the stimulus period. Cyclical gasps were not affected by sympathetic or parasympathetic blockade. These data show that, despite EEG silence, piglets can autoresuscitate by initiating gasps that are not dependent on autonomic integrity. These gasps markedly improve cardiovascular status and may sustain animals for a prolonged period of time.