Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement.
Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement.
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新型可充电磷酸钙纳米颗粒正畸水泥
DOI：
10.1038/ijos.2016.40
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发表时间：
2017-03
影响因子：
14.9
通讯作者：
Xu HH
中科院分区：
文献类型：
--
作者：
Xie XJ;Xing D;Wang L;Zhou H;Weir MD;Bai YX;Xu HH
由于牙釉质脱矿，白斑病变在正畸治疗中经常发生。我们最近开发了一种新型的可充电牙科复合材料，其中含有纳米无定形磷酸钙（NACP），具有长期释放钙（Ca）和磷酸盐(P)离子和抑制龋齿的能力。本研究的目的是开发第一种nacp可充电正畸骨水泥，并研究充电时间和频率对离子再释放效果的影响。该可充电水泥由二甲基丙烯酸甲酯（PMGDM）和乙氧基化双酚A二甲基丙烯酸甲酯（EBPADMA）组成。NACP以40%的质量加入树脂。测试正畸支架与牙釉质剪切结合强度（SBS）、钙、磷离子初释、充注、再释。新型正畸骨水泥的SBS与没有CaP释放的商用正畸骨水泥相似（P> .1）。一次充电处理后的标本（例如，在充电液中浸泡1分钟，一天重复3次，称为“1分钟3次”）在14天内显示出大量和持续的Ca和P离子再释放，而无需进一步充电。离子再释放不随充电/再释放循环次数的增加而减少（P < 0.1）。14天的离子再释放浓度与各种充电处理相比如下：1 min 3次> 3 min 2次> 1 min 2次> 6 min 1次> 3 min 1次> 1 min 1次。综上所述，尽管已有研究表明NACP纳米复合材料可以对牙齿损伤进行再矿化，抑制龋齿，但本研究首次开发出具有钙磷离子补充和长期释放能力的正畸骨水泥。这种nacp -可充电正畸骨水泥是一种很有前途的治疗方法，可以抑制牙釉质脱矿和正畸托槽周围的WSLs。
White spot lesions (WSLs), due to enamel demineralization, occur frequently in orthodontic treatment. We recently developed a novel rechargeable dental composite containing nanoparticles of amorphous calcium phosphate (NACP) with long-term calcium (Ca) and phosphate (P) ion release and caries-inhibiting capability. The objectives of this study were to develop the first NACP-rechargeable orthodontic cement and investigate the effects of recharge duration and frequency on the efficacy of ion re-release. The rechargeable cement consisted of pyromellitic glycerol dimethacrylate (PMGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA). NACP was mixed into the resin at 40% by mass. Specimens were tested for orthodontic bracket shear bond strength (SBS) to enamel, Ca and P ion initial release, recharge and re-release. The new orthodontic cement exhibited an SBS similar to commercial orthodontic cement without CaP release (P> 0.1). Specimens after one recharge treatment (eg, 1 min immersion in recharge solution repeating three times in one day, referred to as “1 min 3 times”) exhibited a substantial and continuous re-release of Ca and P ions for 14 days without further recharge. The ion re-release did not decrease with increasing the number of recharge/re-release cycles (P> 0.1). The ion re-release concentrations at 14 days versus various recharge treatments were as follows: 1 min 3 times> 3 min 2 times> 1 min 2 times> 6 min 1 time> 3 min 1 time> 1 min 1 time. In conclusion, although previous studies have shown that NACP nanocomposite remineralized tooth lesions and inhibited caries, the present study developed the first orthodontic cement with Ca and P ion recharge and long-term release capability. This NACP-rechargeable orthodontic cement is a promising therapy to inhibit enamel demineralization and WSLs around orthodontic brackets.