Cell and tissue morphology determine actin-dependent nuclear migration mechanisms in neuroepithelia

Cell and tissue morphology determine actin-dependent nuclear migration mechanisms in neuroepithelia
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DOI:
10.1083/jcb.201901077
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发表时间:
2019-08
期刊:
The Journal of Cell Biology
影响因子:
--
通讯作者:
I. Yanakieva;A. Erzberger;M. Matejčić;C. Modes;Caren Norden
I. Yanakieva;A. Erzberger;M. Matejčić;C. Modes;Caren Norden
中科院分区:
其他
文献类型:
--
作者:
I. Yanakieva;A. Erzberger;M. Matejčić;C. Modes;Caren Norden

文献摘要

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Yanakieva 等人在发育中的斑马鱼胚胎中使用定量实时成像。表明不同的肌动蛋白依赖性机制将细胞核定位在不同形态的神经上皮中。在弯曲的神经上皮中,发现了一种新的依赖形式的机制,作者为此提出了一个原理验证的理论模型。
Using quantitative live imaging in the developing zebrafish embryo, Yanakieva et al. show that distinct actin-dependent mechanisms position nuclei in neuroepithelia of different morphology. In curved neuroepithelia, a novel formin-dependent mechanism is discovered for which the authors propose a proof-of-principle theoretical model.