The Lang strain of reovirus serotype 1 and the Dearing strain of reovirus serotype 3 differ in their sensitivities to beta interferon.
The Lang strain of reovirus serotype 1 and the Dearing strain of reovirus serotype 3 differ in their sensitivities to beta interferon.
复制标题
呼肠孤病毒血清型 1 的 Lang 株和呼肠孤病毒血清型 3 的 Dearing 株对 β 干扰素的敏感性不同。
DOI：
10.1128/jvi.65.9.5102-5104.1991
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发表时间：
1991
影响因子：
5.4
通讯作者：
Ferguson,RE
中科院分区：
文献类型：
--
作者：
Jacobs,BL;Ferguson,RE
当使用饱和剂量的β干扰素（1，000 IU/ml）时，呼肠孤病毒血清型3的Dearing株在小鼠L细胞中的复制降低17- 100倍。在类似条件下，呼肠孤病毒血清1型的Lang株的复制仅被抑制2 - 3倍。因此，似乎呼肠孤病毒的密切相关的菌株在它们对小鼠L细胞的β干扰素治疗的敏感性方面不同。
Replication of the Dearing strain of reovirus serotype 3 in mouse L cells was decreased 17- to 100-fold when a saturating dose of beta interferon (1,000 IU/ml) was used. Replication of the Lang strain of reovirus serotype 1 was inhibited only two- to threefold under similar conditions. It therefore appears that closely related strains of reovirus differ in their sensitivities to beta interferon treatment of mouse L cells.