Author Correction: Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations.
Author Correction: Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations.
复制标题
作者更正：携带致病性线粒体 DNA 突变的人类卵母细胞的线粒体替代。
DOI：
10.1038/s41586-019-0876-1
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发表时间：
2019
期刊：
影响因子：
64.8
通讯作者：
Li,
中科院分区：
文献类型：
--
作者：
Kang,Eunju;Wu,Jun;Gutierrez,NuriaMarti;Koski,Amy;Tippner-Hedges,Rebecca;Agaronyan,Karen;Platero-Luengo,Aida;Martinez-Redondo,Paloma;Ma,Hong;Lee,Yeonmi;Hayama,Tomonari;VanDyken,Crystal;Wang,Xinjian;Luo,Shiyu;Ahmed,Riffat;Li,
Correction to: Nature https://doi. org/10.1038/nature20592, published online 30 November 2016. Several errors were discovered in this Letter regarding the assignments of mitochondrial (mt) DNA haplotypes for a subset of egg donors from our study. We used whole mtDNA sequencing and then determined the haplotypes by running the sequences through the publicly available MITOMAP database (http://www. mitomap. org/MITOMAP). During this process, the haplotype names were accidentally swapped for egg donors cED4 and hED4, owing to the notational similarity. Specifically, the mtDNA haplotype name H49 was assigned to the carrier egg donor cED4 rather than to the healthy egg donor hED4, which was given the haplotype B2k. Thus, the correct haplotype for cED4 is B2k and for hED4 is H49. In addition, owing to typographic errors in our database, several errors occurred: the haplotype for healthy egg donor hED6 was inaccurately assigned as V3, whereas its correct haplotype is H1g; and the correct donor mtDNA haplotype for NT-ES5 is D4a. The corrected version of Table 1 in the original Letter is shown in Table 1 of this Amendment; the corrected versions of Extended Data Fig. 3a, 5a and 7b in the original Letter are shown in Figs. 1–3 of this Amendment; and the corrected versions of Supplementary Tables 1, 3, 4 and 5 in the original Letter are provided as Supplementary Tables 1–4 with this Amendment; all changes are shown in red. In addition, in Fig. 3 of the original Letter, in all cases ‘H49’(on the y axes and in the legend of panel f) should be ‘B2k’. The changes are summarized in Table 2 of this Amendment.We also identified sequence errors as follows. In Supplementary Table 1 in the original Letter, the nucleotide at mt11253 for H6a haplotype of carrier 1 should be C and the nucleotide at mt11812 for T2b haplotype of carrier 3 should be G. Because the mismatched haplotypes T2 and T2b have the same G at mt11812, the correct distance between these samples is 21 single nucleotide polymorphisms (SNPs), not 22 SNPs as reported in the original Letter. The correct sequences are shown in Supplementary Table 1 of this Amendment, with changes highlighted in red. In Supplementary Table 1 of this Amendment, we have also removed the mt3107 SNP position for U5a haplotype because this nucleotide is probably a hotspot. Therefore, the SNP distance between U5a and H1g is reduced from 33 to 32 in Table 1 and Fig. 1 of this Amendment. The correct B2k haplotype at mt11177 is T and is correct in the ‘Summary’tab of Supplementary Table 4 of this Amendment. We also found typographic errors in Supplementary Tables 1, 3, 4 and 5 of the original Letter in the assignment of several hED numbers: the correct number for original hED7 is hED10; hED10 is hED7; hED6 is hED9; hED9 is hED6; hED8 is hED11; hED11 is hED5; and hED5 is
