ACTIVATION OF SUBFORNICAL ORGAN EFFERENTS STIMULATES OXYTOCIN SECRETION IN THE RAT
ACTIVATION OF SUBFORNICAL ORGAN EFFERENTS STIMULATES OXYTOCIN SECRETION IN THE RAT
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DOI：
10.1016/0167-0115(87)90039-5
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发表时间：
1987-08-03
影响因子：
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通讯作者：
KASTING, NW
中科院分区：
文献类型：
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作者：
FERGUSON, AV;KASTING, NW
在有意识、自由活动的雄性 Sprague-Dawley 大鼠中检查了穹窿下器官 (SFO) 传出神经的激活对血浆催产素浓度的影响。通过长期植入的心房导管获得血样，并使用长期植入的双极刺激电极电激活 SFO 传出神经。通过放射免疫测定法测量激素浓度，根据组织学验证的 SFO、海马连合 (HC) 或内侧隔膜 (MS) 中刺激电极的解剖位置，将实验动物分配到 3 个实验组之一。 SFO 中的电刺激导致催产素血浆浓度从对照值 2.54.+- 增加。 0.9 pg/ml，刺激后水平为 65.6 .+-。 27.0皮克/毫升。相反，刺激紧邻的结构（包括 HC 和 MS）对催产素的血浆浓度没有影响。这些研究提供了第一个明确的证据，证明 SFO 传出神经可能在控制垂体后叶催产素的分泌中发挥重要作用。
The effects of activation of subfornical organ (SFO) efferents on plasma oxytocin concentrations were examined in conscious freely moving male Sprague-Dawley rats. Blood samples were obtained through chronically implanted atrial catheters and SFO efferents were activated electrically using chronically implanted bipolar stimulating electrodes. Hormone concentrations were measured by radioimmunoassay, and experimental animals were assigned to one of 3 experimental groups according to histologically verified anatomical locations of stimulating electrodes in either the SFO, the hippocampal commissure (HC), or the medial septum (MS). Electrical stimulation in the SFO resulted in increased plasma concentrations of oxytocin from control values of 2.54 .+-. 0.9 pg/ml, to a post-stimulation level of 65.6 .+-. 27.0 pg/ml. In contrast, stimulation in immediately adjacent structures including HC and MS was found to be without effect on plasma concentrations of oxytocin. These studies provide the first definitive evidence that SFO efferents may play a significant role in controlling the secretion of oxytocin from the posterior pituitary.