Gastric acid-suppressive therapy and community-acquired respiratory infections
Gastric acid-suppressive therapy and community-acquired respiratory infections
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DOI：
10.1046/j.1365-2036.2003.01744.x
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发表时间：
2003-10-15
影响因子：
7.6
通讯作者：
Jansen, JBMJ
中科院分区：
文献类型：
--
作者：
Laheij, RJF;Van Ijzendoorn, MC;Jansen, JBMJ
背景资料：细菌和病毒已被发现在胃中的病人在抑酸therapy.Aim：探讨是否受试者使用抑酸药物更经常发展社区获得性呼吸道感染时相比，那些谁不使用抑酸drugs.Methods：700名研究对象被招募在一个星期在2002年12月。通过问卷调查评估前一个月感染和并发症临床表现的患病率。此外，受试者被要求报告抗生素治疗和医生访问相关的可能infection.Results：405名受试者（58%）返回的问卷。91例患者报告了抑酸药物的使用，其中79例使用质子泵抑制剂（20%）和12例使用H2受体拮抗剂（3%）。总体而言，101（25%）应答者在前一个月报告了呼吸道感染的临床表现。使用抑酸药物的受试者出现感染临床表现的可能性是未使用抑酸药物的受试者的2.34倍[95%置信区间（CI）1.4 - 4.1]。使用抑酸药物的受试者看医生的频率是其他受试者的3.72倍（95% CI 2.1 - 6.8），接受抗生素治疗的频率为4.19倍（95%CI 2.2 - 8.1）与未使用抑酸药物的个体相比。与未使用抑酸药物的受试者相比，使用抑酸药物的受试者更常报告社区获得性呼吸道感染。
Background: Bacteria and viruses have been detected in the stomach of patients during acid-suppressive therapy.Aim: To investigate whether subjects using acid-suppressive drugs more often develop community-acquired respiratory infections when compared to those who do not use acid-suppressive drugs.Methods: 700 study subjects were recruited during a single week in December 2002. Information on the prevalence of clinical manifestations of infections and complications in the preceding month was assessed by questionnaire. Furthermore, subjects were asked to report antibiotic therapy and physician visits related to possible infection.Results: Questionnaires were returned by 405 subjects (58%). Consumption of acid-suppressive drugs was reported by 91 individuals, of whom 79 used proton-pump inhibitors (20%) and 12 H2-receptor antagonists (3%). Overall, 101 (25%) responders reported clinical manifestations of respiratory infection in the preceding month. Subjects using acid-suppressive drugs were 2.34 times [95% confidence interval (CI) 1.4-4.1] more likely to have clinical manifestations of infection than individuals not using acid-suppressive drugs. Subjects using acid-suppressive drugs visited a physician 3.72 times more often ( 95% CI 2.1-6.8) for an infection and received antibiotic therapy 4.19 times more often ( 95% CI 2.2-8.1) in comparison to individuals not using acid-suppressive drugs.Conclusions: Subjects using acid-suppressive drugs more often reported community-acquired respiratory infections in comparison to those who did not use acid-suppressive drugs.