Loss of diurnal rhythms of blood pressure and heart rate caused by high-fat feeding.
Loss of diurnal rhythms of blood pressure and heart rate caused by high-fat feeding.
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DOI：
10.1016/j.amjhyper.2005.04.018
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发表时间：
2005-10
影响因子：
3.2
通讯作者：
J. Carroll;J. Thaden;Allison M Wright;Taylor Strange
中科院分区：
文献类型：
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作者：
J. Carroll;J. Thaden;Allison M Wright;Taylor Strange
研究背景通过自由采食高脂饲料诱导家兔肥胖，可引起血压和心率昼夜节律的紊乱。由于肥胖与高血压有关，因此很难确定随意喂养和肥胖在改变昼夜节律方面的独立影响。方法将白色新西兰兔分为瘦对照组（LC）、瘦肼苯哒嗪治疗组（LH）、肥胖对照组（OC）和肥胖肼苯哒嗪治疗组（OH），观察各组血压和心率的昼夜节律变化。瘦动物消耗维持饮食，而肥胖动物消耗自由高脂肪饮食。在12周内，使用遥测技术从11：00至07：00监测BP和HR。肼苯哒嗪治疗包括LH和OH分别为6 mg/kg/天和10 - 14 mg/kg/天。结果与对照组相比，高脂喂养第1天大鼠的昼夜心率节律消失（分别为61.4 ± 3.6v3.1 ± 4.2beats/min;P≤ 0.05），而OC和OH在12周内的昼夜心率无显著差异。与对照值相比，高脂喂养第2天的血压昼夜节律消失（分别为4.6 ± 1.6v−0.1 ± 0.9 mm Hg;P≤ .05），而OC和OH的昼夜血压没有差异，尽管OH的血压较低。结论在这项研究中，自由高脂喂养家兔导致血压和心率昼夜节律的立即丧失，这与体重增加和血压升高无关。Am J Hypertens 2005;18：1320-1326 © 2005 American Journal of Hypertension，Ltd.
BackgroundDiet-induced obesity using ad libitum high-fat feeding in rabbits causes losses in diurnal rhythms of blood pressure (BP) and heart rate (HR). Because obesity is associated with hypertension, it is difficult to determine independent effects of ad libitum feeding and obesity in altering diurnal rhythms. We studied diurnal rhythms of BP and HR after controlling BP during obesity development using hydralazine.MethodsNew Zealand white rabbits were divided into lean control (LC), lean hydralazine-treated (LH), obese control (OC), and obese hydralazine-treated (OH) groups. Lean animals consumed a maintenance diet, whereas obese animals consumed an ad libitum high-fat diet. Over 12 weeks, BP and HR were monitored from 11:00 to 07:00 using telemetry. Hydralazine treatment consisted of 6 mg/kg/day and 10 to 14 mg/kg/day for LH and OH, respectively. Diurnal rhythms were evaluated using day–night values (day, 11:00 to 16:00 average; night, 02:00 to 07:00 average).ResultsCompared with control values, diurnal HR rhythm was abolished on day 1 of high-fat feeding (61.4 ± 3.6v3.1 ± 4.2 beats/min, respectively;P≤ .05), whereas OC and OH did not differ significantly in day–night HR over 12 weeks. Compared with control values, diurnal BP rhythm was abolished by day 2 of high-fat feeding (4.6 ± 1.6v−0.1 ± 0.9 mm Hg, respectively;P≤ .05), whereas OC and OH did not differ in day–night BP despite lower BP in OH.ConclusionIn this study ad libitum high-fat feeding in rabbits caused immediate losses of diurnal rhythms of BP and HR that were independent of weight gain and BP elevation. Am J Hypertens 2005;18:1320–1326 © 2005 American Journal of Hypertension, Ltd.