Shedding light on Bronsted acid catalysis - a photocyclization-reduction reaction for the asymmetric synthesis of tetrahydroquinolines from aminochalcones in batch and flow
Shedding light on Bronsted acid catalysis - a photocyclization-reduction reaction for the asymmetric synthesis of tetrahydroquinolines from aminochalcones in batch and flow
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DOI：
10.1039/c3cc43996h
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Rueping, Magnus
中科院分区：
文献类型：
--
作者：
Liao, Hsuan-Hung;Hsiao, Chien-Chi;Rueping, Magnus
利用容易获得的氨基查尔酮类化合物，开发了一种新的不对称光环化还原级联反应。反应顺序采用光化学和不对称Bronsted酸催化相结合的方法，包括光环化、Bronsted酸催化的对映体选择性氢化、间歇反应和流动反应。
A new asymmetric photocyclization-reduction cascade employing readily available aminochalcones has been developed. The reaction sequence has been achieved by unifying photochemistry and asymmetric Bronsted acid catalysis and involves photocyclization followed by Bronsted acid catalyzed enantioselective hydrogenation in batch and flow.